单位：[1]Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, 100029, China[2]Jiangsu Province Key Laboratory of Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China
T-type calcium channels are prominently expressed in primary nociceptive fibers and well characterized in pain processes. Although itch and pain share many similarities including primary sensory fibers, the function of T-type calcium channels on acute itch has not been explored. We investigated whether T-type calcium channels expressed within primary sensory fibers of mouse skin, especially Ca(v)3.2 subtype, involve in chloroquine-, endothelin-1-and histamine-evoked acute itch using pharmacological, neuronal imaging and behavioral analyses. We found that pre-locally blocking three subtypes of T-type calcium channels in the peripheral afferents of skins, yielded an inhibition in acute itch or pain behaviors, while selectively blocking the Ca(v)3.2 channel in the skin peripheral afferents only inhibited acute pain but not acute itch. These results suggest that T-type Ca(v)3.1 or Ca(v)3.3, but not Ca(v)3.2 channel, have an important role in acute itch processing, and their distinctive roles in modulating acute itch are worthy of further investigation. (C) 2017 Elsevier Inc. All rights reserved.
基金：
hospital of China-Japan Friendship Hospital [2015-1-QN-18]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30870832]; Jiangsu Province Distinguished Professor Program
第一作者单位：[1]Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, 100029, China[2]Jiangsu Province Key Laboratory of Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China
共同第一作者：
通讯作者：
通讯机构：[2]Jiangsu Province Key Laboratory of Anesthesiology, School of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China[*1]Room D439, 209 Tongshan Road, Xuzhou, Jiangsu, 221004 China.
推荐引用方式(GB/T 7714)：
Lin Si-Fang,Wang Bing,Zhang Feng-Ming,et al.T-type calcium channels, but not Cav3.2, in the peripheral sensory afferents are involved in acute itch in mice[J].BIOCHEMICAL and BIOPHYSICAL RESEARCH COMMUNICATIONS.2017,487(4):801-806.doi:10.1016/j.bbrc.2017.04.127.
APA：
Lin, Si-Fang,Wang, Bing,Zhang, Feng-Ming,Fei, Yuan-Hui,Gu, Jia-Hui...&Liu, Xing-Jun.(2017).T-type calcium channels, but not Cav3.2, in the peripheral sensory afferents are involved in acute itch in mice.BIOCHEMICAL and BIOPHYSICAL RESEARCH COMMUNICATIONS,487,(4)
MLA：
Lin, Si-Fang,et al."T-type calcium channels, but not Cav3.2, in the peripheral sensory afferents are involved in acute itch in mice".BIOCHEMICAL and BIOPHYSICAL RESEARCH COMMUNICATIONS 487..4(2017):801-806
