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Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study

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收录情况： ◇ SCIE

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单位： [1]Department of Infectious Disease, East Medical District of Linyi People’s Hospital, Linyi 276000, PR China, [2]Department of Infectious Disease, Linyi People’s Hospital, Linyi 276000, PR China, [3]Traditional Chinese Medicine Department of Digestion, China-Japan Friendship Hospital, Beijing 100029, PR China, [4]School of Postgraduate, Dalian Medical University, Dalian 116023, PR China

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A selective and sensitive liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method was developed for the simultaneous determination of ligustroflavone and rhoifolin in rat plasma. Chromatographic separation was performed on a Venusil HILIC column using an isocratic mobile phase consisting of acetonitrile/water/formic acid (75:25:0.1, v/v/v). The detection was achieved using a triple-quadrupole tandem MS in negative ionization through selected reaction monitoring (SRM) mode. The calibration curves of both analytes in plasma showed good linearity over the concentration ranges of 3-300 ng/mL for ligustroflavone, and 2-200 ng/mL for rhoifolin. This assay was used to investigate the pharmacokinetics of ligustroflavone and rhoifolin in rats.

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出版当年[2016]版：

大类 | 4 区化学

小类 | 4 区生化研究方法 4 区分析化学

最新[2025]版：

大类 | 4 区化学

小类 | 4 区生化研究方法 4 区分析化学

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出版当年[2015]版：

Q3 CHEMISTRY, ANALYTICAL Q4 BIOCHEMICAL RESEARCH METHODS

最新[2023]版：

Q3 CHEMISTRY, ANALYTICAL Q4 BIOCHEMICAL RESEARCH METHODS

影响因子： 最新[2023版] 1.5 最新五年平均[2021-2025] 1.6 出版当年[2015版] 1.32 出版当年五年平均[2011-2015] 1.215 出版前一年[2014版] 1.363 出版后一年[2016版] 0.984

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第一作者单位： [1]Department of Infectious Disease, East Medical District of Linyi People’s Hospital, Linyi 276000, PR China,

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