单位：[1]Department of Nephrology, China-Japan Friendship Hospital, Beijing, China[2]Department of Nephrology, Nanchong Central Hospital, Second Clinical Medical Institution of North Sichuan Medical College, Nanchong, China[3]Department of Nephrology, Aerospace Center Hospital, Beijing, China[4]School of Social Development and Public Policy, Beijing Normal University, Beijing, China[5]School of Management Beijing University of Chinese Medicine, Beijing, China[6]Department of Nephrology, Dalian University Affiliated Xinhua Hospital, Dalian, China[7]Department of Nephrology,The Fourth Hospital of Jilin University, Changchun, China[8]Department of Nephrology, Cangzhou People’s Hospital, Cangzhou, China
Background. Secondary hyperparathyroidism (SHPT) usually required parathyroidectomy (PTX) when drugs treatment is invalid. Analysis was done on the impact of different intact parathyroid hormone (iPTH) after the PTX on all-cause mortality. Methods. An open, retrospective, multicenter cohort design was conducted. The sample included 525 dialysis patients with SHPT who had undergone PTX. Results. 404 patients conformed to the standard, with 36 (8.91%) deaths during the 11 years of follow-up. One week postoperatively, different levels of serum iPTH were divided into four groups: A: <= 20 pg/mL; B: 21-150 pg/mL; C: 151-600 pg/mL; and D: >600 pg/mL. All-causemortality in groups with different iPTH levels appeared as follows: A (8.29%), B (3.54%), C (10.91%), and D (29.03%). The all-cause mortality of B was the lowest, with D the highest. We used group A as reference (hazard ratio (HR) = 1) compared with the other groups, and HRs on groups B, C, and D appeared as 0.57, 1.43, and 3.45, respectively. Conclusion. The all-cause mortality was associated with different levels of iPTH after the PTX. We found that iPTH > 600 pg/mL appeared as a factor which increased the risk of all-cause mortality. When iPTH levels were positively and effectively reducing, the risk of all-cause mortality also decreased. The most appropriate level of postoperative iPTH seemed to be 21-150 pg/mL.
基金：
Beijing Municipal Science and Technology Commission Program [Z151100004015112]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
JCR分区：
出版当年[2015]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Department of Nephrology, China-Japan Friendship Hospital, Beijing, China[2]Department of Nephrology, Nanchong Central Hospital, Second Clinical Medical Institution of North Sichuan Medical College, Nanchong, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xi Qiu Ping,Xie Xi Sheng,Zhang Ling,et al.Impact of Different Levels of iPTH on All-Cause Mortality in Dialysis Patients with Secondary Hyperparathyroidism after Parathyroidectomy[J].BIOMED RESEARCH INTERNATIONAL.2017,2017:doi:10.1155/2017/6934706.
APA：
Xi, Qiu Ping,Xie, Xi Sheng,Zhang, Ling,Zhang, Rui,Xiao, Yue Fei...&Du, Shu Tong.(2017).Impact of Different Levels of iPTH on All-Cause Mortality in Dialysis Patients with Secondary Hyperparathyroidism after Parathyroidectomy.BIOMED RESEARCH INTERNATIONAL,2017,
MLA：
Xi, Qiu Ping,et al."Impact of Different Levels of iPTH on All-Cause Mortality in Dialysis Patients with Secondary Hyperparathyroidism after Parathyroidectomy".BIOMED RESEARCH INTERNATIONAL 2017.(2017)
