单位：[1]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China [2]Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China [3]Clinical Laboratory, Peking University International Hospital, Beijing, China
Objectives To perform a meta-analysis to evaluate the diagnostic performance of the antiglycoprotein-2 (GP2) antibody for Crohn's disease (CD). Methods Three databases (EMBASE, ISI Web of Knowledge and PubMed) were systematically searched. There were 17 eligible studies included in the meta-analysis. A total of 2439 patients with CD and 3184 controls were involved in these studies. STATA V.11.2 and Meta-DiSc V.1.4 were used to perform the meta-analysis. Results The area under the summary receiver operating characteristic curve was 0.68-0.72. The pooled diagnostic sensitivity of the anti-GP2 antibody ranged from 14% to 24%, and the specificity was 96%-98%. Conclusions The anti-GP2 antibody is a specific biomarker for CD, and further exploration of its prevalence among different clinical phenotypes of CD will provide a better understanding of its diagnostic performance.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81302591, 81601833, 81501841, 81172857, 81373188]; Research Special Fund for Public Welfare Industry of Health [201202004]; Chinese National High Technology Research and Development Program, Ministry of Science and Technology GrantsNational High Technology Research and Development Program of China [2011AA02A113]; National Science Technology Pillar Program in the 12th Five-year Plan [2014BAI07B00]
第一作者单位：[1]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China
通讯作者：
推荐引用方式(GB/T 7714)：
Deng Chuiwen,Li Wenli,Li Jing,et al.Diagnostic value of the antiglycoprotein-2 antibody for Crohn's disease: a PRISMA-compliant systematic review and meta-analysis[J].BMJ OPEN.2017,7(6):doi:10.1136/bmjopen-2016-014843.
APA：
Deng, Chuiwen,Li, Wenli,Li, Jing,Zhang, Shulan&Li, Yongzhe.(2017).Diagnostic value of the antiglycoprotein-2 antibody for Crohn's disease: a PRISMA-compliant systematic review and meta-analysis.BMJ OPEN,7,(6)
MLA：
Deng, Chuiwen,et al."Diagnostic value of the antiglycoprotein-2 antibody for Crohn's disease: a PRISMA-compliant systematic review and meta-analysis".BMJ OPEN 7..6(2017)
