单位：[1]MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[2]Key Laboratory of Zoonosis, Shenyang Agriculture University, Shenyang, China[3]Beijing Key Laboratory for Research on Prevention and Treatment of Tropical Diseases, Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院
T-cell immunoglobulin and mucin-domain-containing molecule 3 (Tim-3) has complicated roles in regulating monocytes and macrophages in various diseases and it tends to be an inhibitory molecule to facilitate the immune escape of parasites in malaria. However, the mechanisms of Tim-3 mediated responses in monocytes and macrophages in malaria have not been clear. In this study, we found that Plasmodium infection down-regulated Tim-3 expression in peripheral monocytes of patients suffering from Plasmodium falciparum malaria and in splenic macrophages of Plasmodium berghei ANKA-infected mice. Tim-3 signal blockade with anti-Tim-3 antibodies enhanced phagocytosis and parasitical mediator production of murine splenic macrophages during Plasmodium infection. In conclusion, Tim-3 constricts monocytes/macrophages activity, and anti-Tim-3 treatment facilitates parasite clearance, especially in the early stage of Plasmodium infection.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81672050, 81301457, 81420108023]; Chinese Academy of Medical Sciences [2016ZX310064]; Program for Changjiang Scholars and Innovative Research Team in UniversityProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT13007]; Special Fund for Health Research in the Public Interest [201402001]
第一作者单位：[1]MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[2]Key Laboratory of Zoonosis, Shenyang Agriculture University, Shenyang, China
推荐引用方式(GB/T 7714)：
Hou Nan,Jiang Ning,Zou Yang,et al.Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance[J].FRONTIERS in MICROBIOLOGY.2017,8:doi:10.3389/fmicb.2017.01431.
APA：
Hou, Nan,Jiang, Ning,Zou, Yang,Piao, Xianyu,Liu, Shuai...&Chen, Qijun.(2017).Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance.FRONTIERS in MICROBIOLOGY,8,
MLA：
Hou, Nan,et al."Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance".FRONTIERS in MICROBIOLOGY 8.(2017)
