The goal of the work described here was to explore the cause of spleen stiffness (SS) in hepatic fibrogenesis and evaluate the value of SS in liver fibrosis (LF) staging. LF was induced with carbon tetrachloride (CCl4) in rats (n = 40). Supersonic shear wave imaging and contrast-enhanced ultrasound were performed to determine liver stiffness (LS), SS and splenic hemodynamics. SS, LS and free portal pressure exhibited moderate correlations with fibrosis stage (r = 0.744-0.835, p < 0.001). Time-intensity curves of contrast-enhanced ultrasound for the spleen were presented as decreasing peak intensity and slope of decrease, and increasing time to peak. Splenic sinus dilation and congestion were observed on histopathologic analysis. The area under the receiver operating characteristic curve of SS was higher than that of LS for differentiating LF stages 0-2 from stages 3-4 (Z = 2.293, p = 0.02). SS is a reliable diagnostic marker for the assessment of LF in the CCl4 model, especially for severe fibrosis. Elevated portal pressure is the cause of increasing SS. (E-mail: qianlinxue2002@163.com) (C) 2017 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81401425]; Project of High-Talented Personnel in Beijing's Health System [2014-3-009]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区医学
小类|2 区声学3 区核医学
最新[2025]版：
大类|3 区医学
小类|3 区声学3 区核医学
JCR分区：
出版当年[2015]版：
Q1ACOUSTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2ACOUSTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者单位：[1]Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Hu Xiang-Dong,Geng Hui-Ying,Wang Lei,et al.SUPERSONIC SHEAR WAVE IMAGING OF THE SPLEEN FOR STAGING OF LIVER FIBROSIS IN RATS[J].ULTRASOUND in MEDICINE and BIOLOGY.2017,43(10):2343-2351.doi:10.1016/j.ultrasmedbio.2017.04.013.
APA：
Hu, Xiang-Dong,Geng, Hui-Ying,Wang, Lei,Xu, Hu-Feng,Su, Yuan...&Qian, Lin-Xue.(2017).SUPERSONIC SHEAR WAVE IMAGING OF THE SPLEEN FOR STAGING OF LIVER FIBROSIS IN RATS.ULTRASOUND in MEDICINE and BIOLOGY,43,(10)
MLA：
Hu, Xiang-Dong,et al."SUPERSONIC SHEAR WAVE IMAGING OF THE SPLEEN FOR STAGING OF LIVER FIBROSIS IN RATS".ULTRASOUND in MEDICINE and BIOLOGY 43..10(2017):2343-2351
