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miR-138 promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through the SIRT1/p-STAT3 pathway

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收录情况： ◇ SCIE

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单位： [1]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China [2]Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dong Jiao Min Xiang, Dongcheng District, Beijing 100730, China [3]Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China

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Human cytomegalovirus (HCMV) has been reported to be linked to vascular disease through the induction of neovessel formation. We have previously reported that microRNA (miR)-217 and miR-199a-5p enhance endothelial angiogenesis via inhibition of sirtuin 1 (SIRT1) in HCMV-infected human umbilical vein endothelial cells (HUVECs). Here, we found that miR-138 also suppressed the expression of the SIRT1 protein and stimulated phosphorylation of signal transducer and activator of transcription 3 (p-STAT3). Moreover, the regulation of p-STAT3 expression mediated by SIRT1 was found to promote HCMV-induced angiogenesis. These findings revealed that miR-138 might promote angiogenesis of HCMV-infected HUVECs by activating the SIRT1-mediated p-STAT3 pathway, and this could provide novel insights into HCMV-induced angiogenesis.

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出版当年[2016]版：

大类 | 3 区医学

小类 | 4 区病毒学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区病毒学

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出版当年[2015]版：

Q3 VIROLOGY

最新[2023]版：

Q3 VIROLOGY

影响因子： 最新[2023版] 2.5 最新五年平均[2021-2025] 2.2 出版当年[2015版] 2.255 出版当年五年平均[2011-2015] 2.143 出版前一年[2014版] 2.39 出版后一年[2016版] 2.058

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第一作者单位： [3]Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China

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