单位：[1]Department of Pediatrics, the Affiliated Hospital of Qingdao University, QingDao, P.R. China[2]The Chinese people’s liberatin army 401 hospital,Qing Dao,P.R. China[3]Department of Pediatrics, Chinese PLA General Hospital, Beijing, P.R. China[4]Department of Pediatrics, Beijing Friendship Hospital,Capital Medical University, Beijing, P.R. China临床科室儿科儿科首都儿科研究所首都医科大学附属北京友谊医院[5]Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Background: Infantile spasm (IS) is a catastrophic epileptic syndrome of childhood and is usually insensitive to conventional antiepileptic drugs. Studies revealed that prenatal stress (PS) exposure and Melanocortin-2 Receptor (MC2R) may be involved in the pathogenesis of IS. However, the exact mechanism still remains unknown. Methods: In this study, PS was initially given to Wistar rats and ACTH injection was performed in offsprings. Seizure was then induced and evaluated, followed by MC2R immunohistochemistry and expression detection. Results: Significant differences in seizure number, MC2R and CRH expressions were observed among different subgroups. Conclusions: Our study suggested that PS exposure may be an important factor in the pathogenesis of IS. ACTH together with low expression of MC2R, may inhibit IS seizures.
第一作者单位：[1]Department of Pediatrics, the Affiliated Hospital of Qingdao University, QingDao, P.R. China
通讯作者：
通讯机构：[3]Department of Pediatrics, Chinese PLA General Hospital, Beijing, P.R. China[*1]Department of Pediatrics, Chinese PLA General Hospital, 100853, Beijing, China
推荐引用方式(GB/T 7714)：
Zhang Ying,Yuan Shao Yong,Zou Li Ping,et al.ACTH and Low Melanocortin-2 Receptor Expression Inhibit Infantile Spasm (IS) Seizures in Prenatal Stress (PS) Exposed Rats[J].IRANIAN JOURNAL of PEDIATRICS.2017,27(4):doi:10.5812/ijp.8081.
APA：
Zhang, Ying,Yuan, Shao Yong,Zou, Li Ping,Ding, Ying Xue&He, Bing.(2017).ACTH and Low Melanocortin-2 Receptor Expression Inhibit Infantile Spasm (IS) Seizures in Prenatal Stress (PS) Exposed Rats.IRANIAN JOURNAL of PEDIATRICS,27,(4)
MLA：
Zhang, Ying,et al."ACTH and Low Melanocortin-2 Receptor Expression Inhibit Infantile Spasm (IS) Seizures in Prenatal Stress (PS) Exposed Rats".IRANIAN JOURNAL of PEDIATRICS 27..4(2017)
