单位：[1]Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室肾脏内科肾脏内科首都医科大学附属北京友谊医院[2]Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China医技科室影像中心超声医学科首都医科大学附属北京友谊医院
Background: Microwave ablation (MWA) is an effective treatment for severe secondary hyperparathyroidism (SHPT), but it can also be used for mild-to-moderate secondary hyperparathyroidism (SHPT). In this randomised, controlled study, the efficacy of MWA in the treatment of mild-to-moderate hyperparathyroidism is investigated.Materials and methods: We assessed outcomes 12months after the randomisation of 28 patients with mild-to-moderate SHPT. The subjects received either MWA plus calcitriol or calcitriol alone. The primary end-points were the rate of achieving target levels of intact parathyroid hormone (iPTH), changes in iPTH levels and the rate of patients developing severe SHPT.Results: Primary end points: the overall rates of achieving target levels of iPTH were comparable between the MWA and calcitriol alone groups (24% vs. 22%, p=0.85). However, the rate of iPTH <150pg/mL (lower limit of the target range) in the MWA group was higher than that in the calcitriol alone group (23% vs. 8%, p=0.02). The mean iPTH level in the MWA group after MWA was lower than that in the calcitriol alone group (373.09322.31 vs. 552.28 +/- 361.87pg/mL, p<0.001). There was a significant difference in the change in iPTH levels over time within the MWA group (p<0.001) but not in the calcitriol alone group. Only one patient developed severe SHPT in the MWA group, while six patients in the calcitriol alone group developed severe SHPT (p=0.04).Conclusions: Compared with calcitriol alone, MWA plus calcitriol decreases iPTH levels and prevents the progression of mild-to-moderate SHPT.
基金：
Beijing Municipal Administration of Hospitals' Youth Program [QML20160101]; Beijing Municipal Administration of Hospitals Incubating Program [PX2017013]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|3 区医学
小类|2 区核医学3 区肿瘤学
最新[2025]版：
大类|3 区医学
小类|3 区肿瘤学3 区核医学
JCR分区：
出版当年[2015]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2ONCOLOGY
最新[2023]版：
Q2ONCOLOGYQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者单位：[1]Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, 95 Yong’An Road, Beijing, China
推荐引用方式(GB/T 7714)：
Wang Gang,Liu Sha,Liu Xu,et al.Microwave ablation: an effective treatment for mild-to-moderate secondary hyperparathyroidism in patients undergoing haemodialysis[J].INTERNATIONAL JOURNAL of HYPERTHERMIA.2017,33(8):946-952.doi:10.1080/02656736.2017.1357210.
APA：
Wang, Gang,Liu, Sha,Liu, Xu,Qian, Linxue,Diao, Zongli&Liu, Wenhu.(2017).Microwave ablation: an effective treatment for mild-to-moderate secondary hyperparathyroidism in patients undergoing haemodialysis.INTERNATIONAL JOURNAL of HYPERTHERMIA,33,(8)
MLA：
Wang, Gang,et al."Microwave ablation: an effective treatment for mild-to-moderate secondary hyperparathyroidism in patients undergoing haemodialysis".INTERNATIONAL JOURNAL of HYPERTHERMIA 33..8(2017):946-952
