单位：[1]School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine, Beijing 100029, People’s Republic of China [2]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China [3]Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China [4]Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, United States [5]Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, People’s Republic of China
Fifteen new and rare iridoid glucoside dimers, cornusides A-O (1-15), and 10 known iridoid glucosides (16-25) were isolated from the fruit of Cornus officinalis. These new chemical structures were estabhshed through spectroscopic analysis (UV, IR, HRESIMS, ID and 2D NMR). Compounds 1-25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, and 3, 12, 17, 22, and 23 showed inhibitory effects, with IC50 values of 11.9, 12.2, 14.0, 7.0, and 6.9 mu M, respectively.
基金：
'Ten Diseases amp; Ten Drugs' Project of Beijing Municipal Science amp; Technology Commission [Z171100001717009]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473119, 81473590, 81402814]
第一作者单位：[1]School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine, Beijing 100029, People’s Republic of China [2]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ye Xian-Sheng,He Jun,Cheng Yung-Chi,et al.Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis[J].JOURNAL of NATURAL PRODUCTS.2017,80(12):3104-3112.doi:10.1021/acs.jnatprod.6b01127.
APA：
Ye, Xian-Sheng,He, Jun,Cheng, Yung-Chi,Zhang, Lei,Qiao, Hao-Yi...&Xu, Jie-Kun.(2017).Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis.JOURNAL of NATURAL PRODUCTS,80,(12)
MLA：
Ye, Xian-Sheng,et al."Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis".JOURNAL of NATURAL PRODUCTS 80..12(2017):3104-3112
