单位：[1]Research Institute of Digestive Diseases The First Affiliated Hospital of Nanchang University Nanchang, Jiangxi 330006[2]Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006[3]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University,Beijing 100050临床科室国家中心普外分中心普外五科（综合普外科）首都医科大学附属北京友谊医院[4]Department of General Surgery, The First Affiliated Hospital of Nanchang University,Nanchang, Jiangxi 330006, P.R. China
Liver kinase B1 (LKB1) functions as a tumor suppressor gene, and loss in the expression of LKB1 contributes to human carcinogenesis and tumor progression. The present study investigated the association between LKB1 and gastric cancer. SGC-7901 gastric cancer cell lines and 63 patients with gastric cancer were examined in the present study, and lentivirus transfection, reverse transription-quantitative polymerase chain reaction and flow cytometric analyses were performed. By examining the expression of LKB1 using immunohistochemical analyses, the present study found that the expression of LKB1 was reduced in the gastric cancer tissues, and restoration of the expression of LKB1 reduced tumor cell viability, migration rate and the expression of CD44, induced cell cycle arrest at the G2 phase of the cell cycle, and increased the sensitivity of the gastric cancer cells to anticancer drugs. LKB1 protein is a tumor-suppressor in gastric cancer and may be potentially be developed as a novel gene therapy target in the treatment of gastric cancer.
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171952, 81272926, 31460304, 81460374]; Jiangxi Provincial Department of Science and Technology, Technical Support Project [20133BBG70061, 2008]
第一作者单位：[1]Research Institute of Digestive Diseases The First Affiliated Hospital of Nanchang University Nanchang, Jiangxi 330006
通讯作者：
通讯机构：[1]Research Institute of Digestive Diseases The First Affiliated Hospital of Nanchang University Nanchang, Jiangxi 330006[*1]Research Institute of Digestive Diseases, The First Affiliated Hospital of Nanchang University, 17 Yongwaizen Street, Nanchang, Jiangxi 330006, P.R. China
推荐引用方式(GB/T 7714)：
Jiang Shanshan,Chen Rensheng,Yu Jianan,et al.Clinical significance and role of LKB1 in gastric cancer[J].MOLECULAR MEDICINE REPORTS.2016,13(1):249-256.doi:10.3892/mmr.2015.4508.
APA：
Jiang, Shanshan,Chen, Rensheng,Yu, Jianan,Li, Nianshuang,Ke, Rong...&Huang, Deqiang.(2016).Clinical significance and role of LKB1 in gastric cancer.MOLECULAR MEDICINE REPORTS,13,(1)
MLA：
Jiang, Shanshan,et al."Clinical significance and role of LKB1 in gastric cancer".MOLECULAR MEDICINE REPORTS 13..1(2016):249-256
