单位：[1]Department of Neurology, Second Hospital of Tianjin Medical University, Tianjin, PR China,[2]Department of Neurology, Tianjin Huanhu Hospital, Tianjin, PR China,[3]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,首都医科大学附属天坛医院[4]China National Clinical Research Center for Neurological Diseases, Beijing, China,[5]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China,[6]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China,[7]Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China,[8]Department of Neurology, Inner Mongolia People’s Hospital, Inner Mongolia, Hohhot, China,[9]Department of Neurology, Jining No.1 People’s Hospital, Jining, Shandong, China,[10]Department of Neurology, Yanbian University Hospital, Yanji, Jilin Province, China,[11]Department of Neurology, Harbin No. 2 Hospital, Harbin, Heilongjiang, China,[12]Department of Neurology, Yili Friendship Hospital, Yili, Xinjiang Provine, China,[13]Department of Neurology, Taian City Central Hospital, Taian, Shandong Province, China
To investigate potential associations between carotid artery stenosis and cognitive impairment among patients with acute ischemic stroke and to provide important clinical implications. We measured the degree of carotid artery stenosis and recorded the Mini-Mental State Examination score (MMSE) at admission in 3116 acute ischemic stroke patients. The association between carotid stenosis and cognitive impairment assessed by MMSE was tested using multivariate regression analysis. Other clinical variables of interest were also studied. After adjusting for age, gender, education level, marriage, alcohol use, tobacco use, physical activity, hypertension, diabetes, hypercholesterolemia, atrial fibrillation, myocardial infarction and NIHSS (National Institutes of Health Stroke Scale) score, we found that participants with high-grade stenosis of the carotid artery had a higher likelihood of cognitive impairment compared to those without carotid artery stenosis (OR = 1.49, 95% CI: 1.05-2.11, p < 0.001). Left common carotid artery stenosis was associated with cognitive impairment in the univariate analysis, although this effect did not persist after adjustment for the NIHSS score. Cognitive impairment was associated with high-grade stenosis of the right carotid artery.
基金：
Stroke Screening and Prevention Engineering Office of the National Health and Family Planning Commission
第一作者单位：[1]Department of Neurology, Second Hospital of Tianjin Medical University, Tianjin, PR China,[2]Department of Neurology, Tianjin Huanhu Hospital, Tianjin, PR China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wei Yue,Anxin Wang,Runxiu Zhu,et al.Association between Carotid Artery Stenosis and Cognitive Impairment in Stroke Patients: A Cross-Sectional Study[J].PLOS ONE.2016,11(1):doi:10.1371/journal.pone.0146890.
APA：
Wei Yue,Anxin Wang,Runxiu Zhu,Zhongrui Yan,Shouhuan Zheng...&Yong Ji.(2016).Association between Carotid Artery Stenosis and Cognitive Impairment in Stroke Patients: A Cross-Sectional Study.PLOS ONE,11,(1)
MLA：
Wei Yue,et al."Association between Carotid Artery Stenosis and Cognitive Impairment in Stroke Patients: A Cross-Sectional Study".PLOS ONE 11..1(2016)
