单位：[1]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China[2]Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China[3]Department of Gastroenterology, Jinan Central Hospital Affiliated to Shandong University, Jinan, China[4]Department of Gastroenterology, Beijing Tsinghua Chang Gung Hospital, Beijing, China[5]Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China[6]Department of Radiology, China-Japan Friendship Hospital, Beijing, China[7]Rishena Technology Development Co. Ltd., Changzhou, China
Objectives: Colonic electrical stimulation (CES) may have a therapeutic potential for slow transit constipation (STC). This study aimed to evaluate the effects of implantable CES on gastrointestinal transit and defecation, and explore its mechanisms in a canine STC model. Methods: Two pairs of electrodes were implanted in each of the proximal colon and rectosigmoid junction (RSJ). Parameters were individualized according to the symptoms of the stimulated dogs. In the STC model, gastrointestinal transit and defecation were assessed to evaluate the effects of double-site CES, and of double-site CES combined with atropine or N-nitro-L-arginine (L-NNA) in a crossover design. Results: Individualized parameters varied among the animals. The CES significantly shortened gastrointestinal transit time (GITT) and colonic transit time (CTT) compared with sham CES (p = 0.001 and p < 0.001, respectively). Compared with sham CES, the CES also exhibited significantly higher stool frequency and stool consistency score (p = 0.018 and p = 0.001, respectively). Co-treatment with atropine or L-NNA blocked the effects of CES on GITT, CTT, and stool consistency. The stool frequency increased by CES, however, only reduced by co-treatment with L-NNA. Conclusions: This double-site implantable CES can improve the gastrointestinal transit and defecation in a canine STC model, possibly by activating the cholinergic and nitrergic pathways. The CES mode used in this study may be proven feasible in treating STC.
基金：
National High-tech R&D Program (863 Program)National High Technology Research and Development Program of China [2012AA021104]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070299]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区临床神经病学4 区医学：研究与实验
最新[2025]版：
大类|3 区医学
小类|3 区临床神经病学3 区医学：研究与实验
JCR分区：
出版当年[2014]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2CLINICAL NEUROLOGY
最新[2023]版：
Q2CLINICAL NEUROLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China[2]Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
通讯作者：
通讯机构：[1]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China[2]Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China[*1]Department of Gastroenterology, China-Japan Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Chen Shuo,Li Yanmei,Yao Shukun,et al.Implantable Colonic Electrical Stimulation Improves Gastrointestinal Transit and Defecation in a Canine Constipation Model[J].NEUROMODULATION.2016,19(1):108-115.doi:10.1111/ner.12369.
APA：
Chen, Shuo,Li, Yanmei,Yao, Shukun,Zhang, Yanli,Liu, Liang...&Du, Yuhui.(2016).Implantable Colonic Electrical Stimulation Improves Gastrointestinal Transit and Defecation in a Canine Constipation Model.NEUROMODULATION,19,(1)
MLA：
Chen, Shuo,et al."Implantable Colonic Electrical Stimulation Improves Gastrointestinal Transit and Defecation in a Canine Constipation Model".NEUROMODULATION 19..1(2016):108-115
