单位：[1]The State Key Laboratory of Organic−Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China[2]Department of Urology, China−Japan Friendship Hospital, Beijing 100029, China
The influence of surface charge on biodistribution and tumor accumulation remains debatable because most research has been carried out by changing the surface functional groups of nanocarriers. In this work, to avoid the interference of different surface properties such as chemical composition and hydrophilicity, polymeric micelles with uniform PEG coatings and continuously tunable sizes or zeta potentials were developed via a facile route. Therefore, the influence of surface charge on the biological functions of micelles with the same size and surface properties could be well explored. In this case, positive charge was found to enhance both tumor cellular uptake and tumor accumulation. Immunofluorescence staining indicated that the improved tumor accumulation was mainly due to the tumor vasculature targeting of positively charged micelles. It is predicted that efficient drug delivery systems for both tumor vasculature and cancer cell targeting can be realized based on positively charged micelles.
基金：
National Natural Science Foundations of ChinaNational Natural Science Foundation of China (NSFC) [51503013, 51390481, 81472412]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2015M570919]; Ministry of Finance; Ministry of Education of PRCMinistry of Education, China
第一作者单位：[1]The State Key Laboratory of Organic−Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
通讯作者：
推荐引用方式(GB/T 7714)：
Shen Tong,Guan Shuli,Gan Zhihua,et al.Polymeric Micelles with Uniform Surface Properties and Tunable Size and Charge: Positive Charges Improve Tumor Accumulation[J].BIOMACROMOLECULES.2016,17(5):1801-1810.doi:10.1021/acs.biomac.6b00234.
APA：
Shen, Tong,Guan, Shuli,Gan, Zhihua,Zhang, Guan&Yu, Qingsong.(2016).Polymeric Micelles with Uniform Surface Properties and Tunable Size and Charge: Positive Charges Improve Tumor Accumulation.BIOMACROMOLECULES,17,(5)
MLA：
Shen, Tong,et al."Polymeric Micelles with Uniform Surface Properties and Tunable Size and Charge: Positive Charges Improve Tumor Accumulation".BIOMACROMOLECULES 17..5(2016):1801-1810
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