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GR gene polymorphism is associated with inter-subject variability in response to glucocorticoids in patients with myasthenia gravis

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收录情况： ◇ SCIE

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单位： [1]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]Department of Neurology, George Washington University, Washington, DC, USA [3]Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing [4]Department of Neurology, Qilu Hospital of Shandong University, Jinan [5]Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao [6]Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, China [7]Departments of Pharmacology and Physiology, George Washington University, Washington, DC, USA

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关键词： glucocorticoid receptor myasthenia gravis single nucleotide polymorphism treatment efficacy variability

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Background and purposeGlucocorticoids (GCs) are the mainstay treatment of myasthenia gravis (MG). However, wide inter-individual variability exists in the response to GCs. MethodsA Chinese cohort of 257 MG patients treated with GCs was evaluated for the association between 19 single nucleotide polymorphisms in the GR gene and clinical response to the initial 3 month GC therapy. A quantitative MG score decreasing by 3 units or becoming zero was defined as sensitivity to GCs. ResultsThe rs17209237* G allele was less frequent in the GC insensitive group compared with the GC sensitive group [P = 0.013, odds ratio (OR) 0.119]. The rs9324921* A allele was more frequent in the GC insensitive group than in the GC sensitive group (P = 0.046, OR 1.94). Carriers of the rs17209237 G allele were less frequent in the GC insensitive group than in the GC sensitive group (dominant model, P = 0.009). Carriers of the rs9324921 A allele were more frequent in the GC insensitive group than in the GC sensitive group (dominant model, P = 0.037). Multivariate logistic regression revealed that the rs17209237 G allele carrier (P = 0.037, OR 0.12) and disease duration before GC treatment (P = 0.011, OR 3.45) were independent factors that contributed to GC efficacy. Conclusionrs17209237 in the GR gene was identified as an independent factor that contributes to GC efficacy in MG patients. The genetic variations of the GR gene may play a role in predicting response to GC treatment.

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出版当年[2015]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 3 区神经科学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

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出版当年[2014]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 最新[2023版] 4.5 最新五年平均[2021-2025] 4.9 出版当年[2014版] 4.055 出版当年五年平均[2010-2014] 3.786 出版前一年[2013版] 3.852 出版后一年[2015版] 3.956

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第一作者单位： [1]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]Department of Neurology, George Washington University, Washington, DC, USA

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通讯作者：

通讯机构： [2]Department of Neurology, George Washington University, Washington, DC, USA [4]Department of Neurology, Qilu Hospital of Shandong University, Jinan [*1]Department of Neurology, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Jinan 250012, China [*2]Department of Neurology, George Washington University, 2150 Pennsylvania Ave NW, Washington, DC 20037, USA

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GR gene polymorphism is associated with inter-subject variability in response to glucocorticoids in patients with myasthenia gravis

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