单位：[a]Department of Neurology, China-Japanese Friendship Hospital, Beijing[b]Tianjin Key Laboratory of Cerebrovascular and of neurodegenerative diseases, Tianjin Dementia Institute,[c]Department of Neurology, Tianjin Huanhu Hospital, Tianjin,[d]Department of Neurology, Northern Jiangsu Province Hospital, Affiliated to Yangzhou University, Yangzhou, Jiangsu Province,江苏省人民医院[e]Department of Neurology, Xiangya Hospital, Central South University, Changsha,[f]Department of Geriatrics, Shanghai Mental Health Center of Shanghai Jiaotong University School of Medicine, Shanghai,[g]Department of neurology, General Hospital of Tianjin Medical University, Tianjin,[h]Department of Neurology, Qilu Hospital, Shandong university, Shandong,[i]Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing,[j]Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University,[k]First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin,[l]Department of Neurology, Beijing Hospital, Ministry of Health, Beijing,[m]The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu Province,[n]Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
Alzheimer disease (AD) is the most frequent cause of dementia. AD diagnosis, progression, and treatment have not been analyzed nationwide in China. The primary aim of this study was to analyze demographic and clinical characteristics related to cognitive decline in AD patients treated at outpatient clinics in China.We performed a retrospective study of 1993 AD patients at 10 cognitive centers across 8 cities in China from March 2011 to October 2014. Of these, 891 patients were followed for more than 1 year.The mean age at diagnosis was 72.010.0 years (range 38-96 years), and the mean age at onset of AD was 69.8 +/- 9.5 years. Most patients (65.1%) had moderate to severe symptoms at the time of diagnosis, and mean Mini-Mental State Examination at diagnosis was 15.7 +/- 7.7. AD patients showed significant cognitive decline at 12 months after diagnosis. Having more than 9 years of formal education was an independent risk factor related to rapid cognitive decline [odds ratio (OR) = 1.80; 95% confidence interval (95% CI): 1.11-2.91]. Early-onset AD patients experienced more rapid cognitive decline than late-onset patients (OR = 1.83; 95% CI: 1.09-3.06).Most AD patients in China had moderate to severe symptoms at the time of diagnosis and experienced significant cognitive decline within 1 year. Rapid cognitive decline in AD was related to having a higher educational level and younger age of onset.
基金：
Tianjin Science and Technology Support Programs [12ZCZDSY02900, 13ZCZDSY01600]; Science and Technology Project of Tianjin Municipal Health Bureau [2014KR10]; Tianjin Natural Science FoundationNatural Science Foundation of Tianjin [13JCYBJC21300]
第一作者单位：[a]Department of Neurology, China-Japanese Friendship Hospital, Beijing
共同第一作者：
通讯作者：
通讯机构：[b]Tianjin Key Laboratory of Cerebrovascular and of neurodegenerative diseases, Tianjin Dementia Institute,[c]Department of Neurology, Tianjin Huanhu Hospital, Tianjin,[*1]Department of Neurology, Tianjin Huanhu Hospital, Qixiangtai Road 122, Hexi, Tianjin 300060, China
推荐引用方式(GB/T 7714)：
Peng Dantao,Shi Zhihong,Xu Jun,et al.Demographic and clinical characteristics related to cognitive decline in Alzheimer disease in China: A multicenter survey from 2011 to 2014[J].MEDICINE.2016,95(26):doi:10.1097/MD.0000000000003727.
APA：
Peng, Dantao,Shi, Zhihong,Xu, Jun,Shen, Lu,Xiao, Shifu...&Ji, Yong.(2016).Demographic and clinical characteristics related to cognitive decline in Alzheimer disease in China: A multicenter survey from 2011 to 2014.MEDICINE,95,(26)
MLA：
Peng, Dantao,et al."Demographic and clinical characteristics related to cognitive decline in Alzheimer disease in China: A multicenter survey from 2011 to 2014".MEDICINE 95..26(2016)
