单位：[1]Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China[2]Department of Vascular and Endovascular Surgery, Shanxian Dongda Hospital, Heze, Shandong[3]Department of Nephrology, Chinese-Japan Friendship Hospital, Beijing, China
Background:Abdominal aortic aneurysm (AAA) is a life-threatening condition. A number of studies reported the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and AAA risk, but substantial controversial findings were observed and the strength of the association remains unclear.Objective:The aim of this study was to investigate the aforementioned association in the overall population and different subgroups.Methods:PUBMED and EMBASE databases were searched until March 2016 to identify eligible studies, restricted to humans and articles published in English. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to AAA. Subgroup meta-analyses were conducted on features of the population, such as ethnicity, sex of the participants, and study design (source of control).Results:Twelve case-control studies on MTHFR C677T polymorphism and AAA risk, including 3555 cases and 6568 case-free controls were identified. The results revealed no significant association between the MTHFR C677T polymorphism and AAA risk in the overall population and within Caucasian or Asian subpopulations in all 5 genetic models. Further subgroup meta-analysis indicated that significantly increased risks were observed among cases with a mean age <70 years (OR = 1.73, 95% CI = 1.10-2.12, P = 0.02), cases with prevalence of smoking <60% (OR = 1.39, 95% CI = 1.02-1.90, P = 0.04), and cases with aneurysm diameter 55mm (OR = 1.55, 95% CI = 1.07-2.24, P = 0.02) in the dominant genetic model. No publication bias was detected in the present study.Conclusion:In conclusion, our comprehensive meta-analysis suggests that the MTHFR C677T polymorphism may play an important role in AAA susceptibility, especially in younger, non-smoking, larger AAA-diameter subgroups of patients
基金：
Chinese Scholarship Council (CSC)China Scholarship Council; Eleventh Five-year Plan in Health Care Foundation of PLA [09BJZ04]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30940070]
第一作者单位：[1]Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China[*1]Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 28 Fuxing Rd, Haidian District, Beijing 100853, China
推荐引用方式(GB/T 7714)：
Liu Jie,Jia Xin,Li Haifeng,et al.Association between MTHFR C677T polymorphism and abdominal aortic aneurysm risk: A comprehensive meta-analysis with 10,123 participants involved[J].MEDICINE.2016,95(36):doi:10.1097/MD.0000000000004793.
APA：
Liu, Jie,Jia, Xin,Li, Haifeng,Jia, Senhao,Zhang, Minhong...&Guo, Wei.(2016).Association between MTHFR C677T polymorphism and abdominal aortic aneurysm risk: A comprehensive meta-analysis with 10,123 participants involved.MEDICINE,95,(36)
MLA：
Liu, Jie,et al."Association between MTHFR C677T polymorphism and abdominal aortic aneurysm risk: A comprehensive meta-analysis with 10,123 participants involved".MEDICINE 95..36(2016)
