单位：[1]National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, People's Republic of China.临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院[2]School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, People's Republic of China[3]Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University, People's Republic of China首都医科大学附属同仁医院[4]Department of Gastroenterology, Affiliated Hospital of Weifang Medical University, People's Republic of China
The early detection of esophageal squamous cell carcinoma (ESCC), one of the most common human neoplasms, is of great importance in improving prognosis. However, there is a lack of screening methods with high sensitivity for early diagnosis of ESCC. In this study, we developed a alpha v beta 3 integrin targeted near-infrared (NIR) fluorescence nanoprobe by conjugation of NIR dye Cy5.5 and tumor vasculature targeted cyclic RGDfK peptide onto a polyamidoamine (PAMAM) dendrimer (RGD-PEG-PAMAM-Cy5.5). The applicability of the as-prepared targeted nanoprobe for NIR fluorescence imaging of 4-NQO induced large and tiny esophageal neoplasms in mice was examined. It was demonstrated that the NIR fluorescence imaging with our targeted nanoprobe enables the identification of ESCC at an early stage.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81271639, 81570507]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z151100003915097]; Capital Health Research and Development of special [2014-1-2021]; Capital Medical University Basic-Clinical Research Cooperation Fund [16JL46]
第一作者单位：[1]National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, People's Republic of China.
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推荐引用方式(GB/T 7714)：
Li Qi,Gu Wei,Liu Kang,et al.RGD conjugated, Cy5.5 labeled polyamidoamine dendrimers for targeted near-infrared fluorescence imaging of esophageal squamous cell carcinoma[J].RSC ADVANCES.2016,6(78):74560-74566.doi:10.1039/c6ra12927g.
