Introduction: Stimulating a successful host immune response may be a promising helpful therapy to achieve elimination of hepatitis B virus (HBV) infection in chronic hepatitis B (CHB). Thymosin alpha-1 (T alpha-1), as an immunomodulatory agent, can enhance T-cell response in CHB patients and has been widely studied either alone or in combination with nucleos(t)ide analogs. This editorial reviews these articles to present the efficacy of T alpha-1 in CHB. Areas covered: English and Chinese articles in MEDLINE, EMBASE, the Cochrane Controlled Trial Registry, Chinese periodical full-text database of science and technology, Chinese periodical full-text database and Wan-fang database by thesis search were collected and reviewed. Expert opinion: In CHB, T alpha-1monotherapy is effective in suppressing viral replication compared with untreated control or conventional interferon. Most of the combination therapy of T alpha-1 plus either lamivudine or IFN-alpha showed better effects on HBV DNA suppression and HBeAg seroconversion. Presently, clinical studies of T alpha-1 combined with entecavir on the treatment of HBV-cirrhosis are ongoing.
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|3 区医学
小类|3 区生物工程与应用微生物3 区医学：研究与实验
最新[2025]版：
大类|3 区医学
小类|3 区生物工程与应用微生物4 区医学：研究与实验
JCR分区：
出版当年[2013]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1BIOTECHNOLOGY & APPLIED MICROBIOLOGY
最新[2023]版：
Q2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing Key Lab Translat Med Liver Cirrhosis, Beijing 100050, Peoples R China[2]Natl Clin Res Ctr Digest Dis, Beijing 100050, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing Key Lab Translat Med Liver Cirrhosis, Beijing 100050, Peoples R China[2]Natl Clin Res Ctr Digest Dis, Beijing 100050, Peoples R China[*1]Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing Key Lab Translat Med Liver Cirrhosis, 95 Yong An Rd, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Wu Xiaoning,Jia Jidong,You Hong.Thymosin alpha-1 treatment in chronic hepatitis B[J].EXPERT OPINION on BIOLOGICAL THERAPY.2015,15:S129-S132.doi:10.1517/14712598.2015.1007948.
APA：
Wu, Xiaoning,Jia, Jidong&You, Hong.(2015).Thymosin alpha-1 treatment in chronic hepatitis B.EXPERT OPINION on BIOLOGICAL THERAPY,15,
MLA：
Wu, Xiaoning,et al."Thymosin alpha-1 treatment in chronic hepatitis B".EXPERT OPINION on BIOLOGICAL THERAPY 15.(2015):S129-S132
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