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Topical Application of Tranexamic Acid Plus Diluted Epinephrine Reduces Postoperative Hidden Blood Loss in Total Hip Arthroplasty

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收录情况： ◇ SCIE

作者：

单位： [1]Natl Hlth & Family Planning Commiss Peoples Repub, Osteonecrosis & Joint Preserving & Reconstruct Ct, Dept Orthoped Surg, Beijing Key Lab Arthrit & Rheumat Dis,China Japan, Beijing, Peoples R China

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关键词： topical tranexamic acid epinephrine transfusion hidden blood loss total hip arthroplasty

摘要：

We evaluated the efficacy and safety of topical application of tranexamic acid (TXA) plus diluted epinephrine (DEP) and its effect on perioperative hidden blood loss and transfusion requirement in primary unilateral total hip arthroplasty (THA). We randomized 107 patients undergoing THA into two groups: 53 received intra-articular TXA 3 g plus 1: 200,000 DEP 0.25 mg; 54 received topical TXA 3 g alone. Results showed that combined administration significantly reduced total blood loss (P = 0.009), hidden blood loss (P = 0.001) and transfusion rate (1.9 vs. 9.3%) compared with TXA alone, without increasing the risks of thromboembolic and hemodynamic complications. Topical TXA plus DEP in THA can decrease postoperative hidden blood loss and avoid homologous transfusion without substantial complications. (C) 2015 Elsevier Inc. All rights reserved.

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中科院(CAS)分区：

出版当年[2014]版：

大类 | 3 区医学

小类 | 3 区骨科

最新[2025]版：

大类 | 2 区

医学

小类 | 2 区骨科

JCR分区：

出版当年[2013]版：

Q2 ORTHOPEDICS

最新[2023]版：

Q1 ORTHOPEDICS

影响因子： 最新[2023版] 3.4 最新五年平均[2021-2025] 4 出版当年[2013版] 2.369 出版当年五年平均[2009-2013] 2.562 出版前一年[2012版] 2.11 出版后一年[2014版] 2.666

第一作者：

第一作者单位： [1]Natl Hlth & Family Planning Commiss Peoples Repub, Osteonecrosis & Joint Preserving & Reconstruct Ct, Dept Orthoped Surg, Beijing Key Lab Arthrit & Rheumat Dis,China Japan, Beijing, Peoples R China

通讯作者：

通讯机构： [1]Natl Hlth & Family Planning Commiss Peoples Repub, Osteonecrosis & Joint Preserving & Reconstruct Ct, Dept Orthoped Surg, Beijing Key Lab Arthrit & Rheumat Dis,China Japan, Beijing, Peoples R China [*1]China Japan Friendship Hosp, Dept Orthoped Surg, Beijing 100029, Peoples R China

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