单位：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China临床科室国家中心普外分中心普外五科（综合普外科）首都医科大学附属北京友谊医院[2]Beijing Key Lab Canc Invas & Metastasis Res, Beijing 100050, Peoples R China[3]Natl Clin Res Ctr Digest Dis, Beijing 100050, Peoples R China首都医科大学附属北京友谊医院[4]Tongji Univ, East Hosp, Dept Med Oncol, Sch Med, Shanghai 200120, Peoples R China
Inorganic pyrophosphatase (PPA1) is an enzyme which has been found to be upregulated in various tumors, yet its profile in gastrointestinal cancers has not systemically investigated. In present study, gastrointestinal tissue microarrays were used to evaluate PPA1 expression and the association of PPA1 expression with clinical outcomes was determined for patients with gastric cancer by immunohistochemistry. Overexpression of PPA1 was observed in cancers of the esophagus, stomach, and pancreaticobiliary system. PPA1 was overexpressed in 143 cases (51.3%) of the 279 primary gastric tumors and was associated with larger size (> 3 cm), nodal metastasis and advanced clinical staging (P < 0.05). Moreover, survival analysis demonstrated that PPA1 expression was significantly correlated reduced overall of patients with gastric cancer. Therefore, PPA1 may serve as a potential biomarker of poor prognosis in patients with gastric cancer.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81172317, 30972887, 81572856]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201504]
第一作者单位：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China[2]Beijing Key Lab Canc Invas & Metastasis Res, Beijing 100050, Peoples R China[3]Natl Clin Res Ctr Digest Dis, Beijing 100050, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China[2]Beijing Key Lab Canc Invas & Metastasis Res, Beijing 100050, Peoples R China[3]Natl Clin Res Ctr Digest Dis, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Yingchi,Cai Jun,Yin Jie,et al.Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer[J].INTERNATIONAL JOURNAL of CLINICAL and EXPERIMENTAL PATHOLOGY.2015,8(10):12482-12490.
APA：
Yang, Yingchi,Cai, Jun,Yin, Jie,Wang, Dong,Bai, Zhigang...&Zhang, Zhongtao.(2015).Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer.INTERNATIONAL JOURNAL of CLINICAL and EXPERIMENTAL PATHOLOGY,8,(10)
MLA：
Yang, Yingchi,et al."Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer".INTERNATIONAL JOURNAL of CLINICAL and EXPERIMENTAL PATHOLOGY 8..10(2015):12482-12490
