The expression of miR-203 has been reported to be significantly down-regulated in esophageal cancer. We showed here that overexpression of miR-203 in esophageal cancer cells dramatically increased cell apoptosis and inhibited cell proliferation, migration and invasion as well as tumor growth and down-regulated miR-21 expression. We subsequently identified that small GTPase Ran was a target gene of miR-203. Furthermore, Ran restoration partially counteracted the tumor suppressive effects of miR-203 and increased miR-21 expression. Taken together, our findings suggest that miR-203 may act as novel tumor suppressor in esophageal cancer through down-regulating the expression of Ran and miR-21. (C) 2013 Elsevier Ireland Ltd. Published by Elsevier Ltd. All rights reserved.
基金：
National High Technology Research and Development Program of China (863 Program)National High Technology Research and Development Program of China [2007AA021107]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [5072004]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [39015001200801]
第一作者单位：[1]Beijing Univ Technol, Coll Life Sci & Bioengn, Dept Pharmacol & Biol, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Beijing Univ Technol, Coll Life Sci & Bioengn, Dept Pharmacol & Biol, Beijing, Peoples R China[*1]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Fang,Yang Zhiping,Cao Minjun,et al.MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer[J].CANCER LETTERS.2014,342(1):121-129.doi:10.1016/j.canlet.2013.08.037.
APA：
Zhang, Fang,Yang, Zhiping,Cao, Minjun,Xu, Yinsheng,Li, Jintao...&Zeng, Yi.(2014).MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer.CANCER LETTERS,342,(1)
MLA：
Zhang, Fang,et al."MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer".CANCER LETTERS 342..1(2014):121-129
医学