单位：[1]Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100730, Peoples R China[2]Peking Union Med Coll, Beijing 100021, Peoples R China[3]MicuRx Pharmaceut Inc, Hayward, CA USA[4]Capital Med Univ, Beijing Friendship Hosp, Beijing, Peoples R China首都医科大学附属北京友谊医院
MRX-I is a potent oxazolidinone antibiotic against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), penicillin-intermediate S. pneumoniae (PISP), and vancomycin-resistant enterococci (VRE). In this study, the in vivo efficacy of orally administered MRX-I was evaluated using linezolid as a comparator. MRX-I showed the same or better efficacy than linezolid in both systemic and local infection models against the tested strains.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30901876, 81273427]; National Mega-project for Innovative Drugs, People's Republic of China [2012ZX09301002-001, 2012ZX09301002-005]
第一作者单位：[1]Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100730, Peoples R China[2]Peking Union Med Coll, Beijing 100021, Peoples R China
通讯作者：
通讯机构：[1]Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100730, Peoples R China[2]Peking Union Med Coll, Beijing 100021, Peoples R China
推荐引用方式(GB/T 7714)：
Li Cong-Ran,Zhai Qian-Qian,Wang Xiu-Kun,et al.In Vivo Antibacterial Activity of MRX-I, a New Oxazolidinone[J].ANTIMICROBIAL AGENTS and CHEMOTHERAPY.2014,58(4):2418-2421.doi:10.1128/AAC.01526-13.
APA：
Li, Cong-Ran,Zhai, Qian-Qian,Wang, Xiu-Kun,Hu, Xin-Xin,Li, Guo-Qing...&You, Xue-Fu.(2014).In Vivo Antibacterial Activity of MRX-I, a New Oxazolidinone.ANTIMICROBIAL AGENTS and CHEMOTHERAPY,58,(4)
MLA：
Li, Cong-Ran,et al."In Vivo Antibacterial Activity of MRX-I, a New Oxazolidinone".ANTIMICROBIAL AGENTS and CHEMOTHERAPY 58..4(2014):2418-2421
医学