The purpose of this study was to compare the clinical outcomes of impacted bone graft with or without recombinant human bone morphogenetic protein-2 (rhBMP-2) for osteonecrosis of the femoral head (ONFH). We examined the effect of bone-grafting through a window at the femoral head-neck junction, known as the "light bulb" approach, for the treatment of ONFH with a combination of artificial bone (Novobone) mixed with or without rhBMP-2. A total of 42 patients (72 hips) were followed-up from 5 to 7.67 years (average of 6.1 years). The patients with and without BMP were the first group (IBG+ rhBMP-2) and the second group (IBG), respectively. The clinical effectiveness was evaluated by Harris hip score (HHS). The radiographic follow-up was evaluated by pre- and postoperative X-ray and CT scan. Excellent, good, and fair functions were obtained in 36, 12, and 7 hips, respectively. The survival rate was 81.8% and 71.8% in the first and second group, respectively. However, the survival rate was 90.3% in ARCO stage IIb, c, and only 34.6% in ARCO stage IIIa(P<0.05). It was concluded that good and excellent mid-term follow-up could be achieved in selected patients with ONFH treated with impacted bone graft operation. The rhBMP-2 might improve the clinical efficacy and quality of bone repair.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372013]; Research Fund of China-Japan Friendship Hospital [2013-MS-27]; China-Japan Friendship Hospital Youth Science and technology excellence project [2014-QNYC-A-06]
第一作者单位:[1]China Japan Friendship Hosp, Ctr Osteonecrosis & Joint Preserving & Reconstruc, Beijing, Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Sun Wei,Li Zirong,Gao Fuqiang,et al.Recombinant Human Bone Morphogenetic Protein-2 in Debridement and Impacted Bone Graft for the Treatment of Femoral Head Osteonecrosis[J].PLOS ONE.2014,9(6):doi:10.1371/journal.pone.0100424.
APA:
Sun, Wei,Li, Zirong,Gao, Fuqiang,Shi, Zhencai,Zhang, Qidong&Guo, Wanshou.(2014).Recombinant Human Bone Morphogenetic Protein-2 in Debridement and Impacted Bone Graft for the Treatment of Femoral Head Osteonecrosis.PLOS ONE,9,(6)
MLA:
Sun, Wei,et al."Recombinant Human Bone Morphogenetic Protein-2 in Debridement and Impacted Bone Graft for the Treatment of Femoral Head Osteonecrosis".PLOS ONE 9..6(2014)