In this study, we report the antibacterial activities of six polyphenols (i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol) against 29 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremia. The antibacterial activities were determined by agar dilution method, and the two-drug antibacterial activities were determined by the checkerboard agar dilution method. It was found that luteolin, quercetin and resveratrol show obvious antibacterial activities against MRSA, and the results of two-drug antibacterial activity show either synergy or additivity, without evidences of antagonistic effects.
基金：
Capital Medical Development Fund [SF-2009-I-11]; Beijing Municipal Bureau of Traditional Chinese Medicine; Scientific Research Fund, Beijing Friendship Hospital [2011-5]
第一作者单位：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Infect & Crit Care Med, Beijing 100050, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Su Yanli,Ma Liyan,Wen Yan,et al.Studies of the in Vitro Antibacterial Activities of Several Polyphenols against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus[J].MOLECULES.2014,19(8):12630-12639.doi:10.3390/molecules190812630.
APA：
Su, Yanli,Ma, Liyan,Wen, Yan,Wang, Hong&Zhang, Shuwen.(2014).Studies of the in Vitro Antibacterial Activities of Several Polyphenols against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus.MOLECULES,19,(8)
MLA：
Su, Yanli,et al."Studies of the in Vitro Antibacterial Activities of Several Polyphenols against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus".MOLECULES 19..8(2014):12630-12639
