单位：[1]Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China[2]Chinese Acad Med Sci, Beijing 100050, Peoples R China[3]China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China
Two new rearranged derivatives of flavonoid C-glycosides, saffloflavonesides A (1) and B (2), were isolated from the florets of Carthamus tinctorius. Their structures were determined using UV, IR, HRESIMS, and 1D and 2D NMR data and by comparing experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1 and 2 were unprecedented chalcone and flavanone derivatives possessing a furan conjoining tetrahydrofuran ring. A potential biosynthetic pathway was proposed. At 10 mu M, 1 and 2 both showed strong inhibitory activity against PC12 cell damage induced by rotenone.
基金：
National Science and Technology Project of China [2012ZX09301002-001003]; Fundamental Research Funds for the Central Institutes [2012ZD03]
第一作者单位：[1]Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China[2]Chinese Acad Med Sci, Beijing 100050, Peoples R China[3]China Japan Friendship Hosp, Dept Pharm, Beijing 100029, Peoples R China
通讯作者：
通讯机构：[1]Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China[2]Chinese Acad Med Sci, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
He Jun,Yang Ya-Nan,Jiang Jian-shuang,et al.Saffloflavonesides A and B, Two Rearranged Derivatives of Flavonoid C-glycosides with a Furan Tetrahydrofuran Ring from Carthamus tinctorius[J].ORGANIC LETTERS.2014,16(21):5714-5717.doi:10.1021/ol502789x.
APA：
He, Jun,Yang, Ya-Nan,Jiang, Jian-shuang,Feng, Zi-Ming&Zhang, Pei-Cheng.(2014).Saffloflavonesides A and B, Two Rearranged Derivatives of Flavonoid C-glycosides with a Furan Tetrahydrofuran Ring from Carthamus tinctorius.ORGANIC LETTERS,16,(21)
MLA：
He, Jun,et al."Saffloflavonesides A and B, Two Rearranged Derivatives of Flavonoid C-glycosides with a Furan Tetrahydrofuran Ring from Carthamus tinctorius".ORGANIC LETTERS 16..21(2014):5714-5717
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