Accumulated evidences supported IL-8 play an important role during colorectal carcinogenesis. However, few direct-related evidences are available. In this paper, we found that high level of IL-8 was constitutively present both in familial adenomatous polyposis (FAP) tissue and carcinoma tissue. Using primary epithelial cells from FAP samples, we study IL-8 effect on their growth, migration, and colonies formation. The results showed that IL-8 stimulated cells proliferation, migration, and colonies formation. Furthermore, High level of CEA, CK20, and EGFR was detected after exposure to IL-8 in primary epithelial cells. In conclusion, our findings showed that IL-8 promotes the adenoma-carcinoma transition in primary epithelial cells from FAP. Targeting IL-8 at adenoma stage may prevent or reduce carcinogenesis.
第一作者单位：[1]China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China
通讯作者：
通讯机构：[2]Weifang Peoples Hosp, Dept Anorectal Surg, Weifang 261041, Shandong, Peoples R China[*1]Weifang Peoples Hosp, Dept Anorectal Surg, 151 Guangwen St, Weifang 261041, Shandong, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Fang,Yu Chen.IL-8 Promote Carcinogenesis of Primary Epithelial Cells From Familial Adenomatous Polyposis[J].CELL BIOCHEMISTRY and BIOPHYSICS.2014,70(3):1765-1771.doi:10.1007/s12013-014-0126-y.
APA：
Liu, Fang&Yu, Chen.(2014).IL-8 Promote Carcinogenesis of Primary Epithelial Cells From Familial Adenomatous Polyposis.CELL BIOCHEMISTRY and BIOPHYSICS,70,(3)
MLA：
Liu, Fang,et al."IL-8 Promote Carcinogenesis of Primary Epithelial Cells From Familial Adenomatous Polyposis".CELL BIOCHEMISTRY and BIOPHYSICS 70..3(2014):1765-1771
