单位：[1]Department of Endocrinology, Key Laboratory of Diabetes Prevention and Control, China-Japan Friendship Hospital, Beijing, China[2]Department of Bioinformatics,Beijing Genetics Institute, Shenzhen, Guangdong, China深圳市康宁医院深圳医学信息中心[3]Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China[4]Department ofEndocrinology, Henan Provincial People’s Hospital, Zhengzhou, Henan, China, 5 Department of Endocrinology, Second Affiliated Hospital of Harbin Medical University,Harbin, Heilongjiang, China[6]Department of Endocrinology, Xinjiang Uygur Autonomous Region’s Hospital, Urmqi, Xinjiang, China[7]Department of Endocrinology,Fujian Provincial Hospital, Fuzhou, Fujian, China[8]Department of Endocrinology, Peking University First Hospital, Beijing, China[9]Department of Endocrinology, ChinesePeople’s Liberation Army General Hospital, Beijing, China[10]Department of Endocrinology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong,China中山大学附属第三医院[11]Department of Endocrinology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China[12]Department of Endocrinology, PekingUniversity People’s Hospital, Beijing, China[13]Department of Endocrinology, First Hospital of China Medical University, Shenyang, Liaoning, China[14]Department ofEndocrinology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China[15]Department of Endocrinology, West China Hospital of Sichuan University, Chengdu,Sichuan, China四川大学华西医院[16]Department of Endocrinology, Xijing Hospital of Fourth Military Medical University, Xi’an, Shaanxi, China[17]Department of Endocrinology, AffiliatedDrum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China[18]Department of Endocrinology, Xiangya Second Hospital, Changsha, Hunan, China[19]Department of Epidemiology, Peking Union Medical College, Beijing, China
Background: Though multiple single nucleotide polymorphisms (SNPs) associated with type 2 diabetes have been identified, the genetic bases of isolated fasting hyperglycaemia (IFH) and isolated postprandial hyperglycaemia (IPH) were still unclear. In present study, we aimed to investigate the association of genome-wide association study-validated genetic variants and IFH or IPH in Han Chinese. Methods/Principal Findings: We genotyped 27 validated SNPs in 6,663 unrelated individuals comprising 341 IFH, 865 IPH, 1,203 combined fasting hyperglycaemia and postprandial hyperglycaemia, and 4,254 normal glycaemic subjects of Han ancestry. The distributions of genotype frequencies of FTO, CDKAL1 and GCKR were significant different between individuals with IFH and those with IPH (SNP(p(trend)): rs8050136(0.0024), rs9939609(0.0049), rs7756992(0.0122), rs780094(0.0037)). Risk allele of FTO specifically increased the risk of IFH (rs8050136: OR 1.403 [95% CI 1.125-1.750], p = 0.0027; rs9939609: 1.398 [1.120-1.744], p = 0.0030). G allele of CDKAL1 specifically increased the risk of IPH (1.217 [1.092-1.355], p = 0.0004). G allele of GCKR increased the risk of IFH (1.167 [0.999-1.362], p = 0.0513), but decreased the risk of IPH (0.891 [0.801-0.991], p = 0.0331). In addition, TCF7L2 and KCNQ1 increased the risk of both IFH and IPH. When combined, each additional risk allele associated with IFH increased the risk for IFH by 1.246-fold (p < 0.0001), while each additional risk allele associated with IPH increased the risk for IPH by 1.190-fold (p < 0.0001). Conclusion/Significance: Our results indicate that genotype distributions of variants from FTO, GCKR, CDKAL1 were different between IPH and IFH in Han Chinese. Variants of genes modulating insulin sensitivity (FTO, GCKR) contributed to the risk of IFH, while variants of genes related to beta cell function (CDKAL1) increase the risk of IPH.
基金：
Chinese Medical Association Foundation; Chinese Diabetes Society; National 973 ProgramNational Basic Research Program of China [2011CB504001]; China Postdoctoral Science Foundation GrantChina Postdoctoral Science Foundation [2012M520200]
第一作者单位：[1]Department of Endocrinology, Key Laboratory of Diabetes Prevention and Control, China-Japan Friendship Hospital, Beijing, China
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推荐引用方式(GB/T 7714)：
Kong Xiaomu,Hong Jing,Chen Ying,et al.Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population[J].PLOS ONE.2013,8(8):doi:10.1371/journal.pone.0071399.
APA：
Kong, Xiaomu,Hong, Jing,Chen, Ying,Chen, Li,Zhao, Zhigang...&Yang, Wenying.(2013).Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population.PLOS ONE,8,(8)
MLA：
Kong, Xiaomu,et al."Association of Genetic Variants with Isolated Fasting Hyperglycaemia and Isolated Postprandial Hyperglycaemia in a Han Chinese Population".PLOS ONE 8..8(2013)
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