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Two new vinblastine-type N-oxide alkaloids from Catharanthus roseus

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收录情况： ◇ SCIE

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单位： [1]China Japan Friendship Hosp, Inst Clin Med Sci, Dept Pharmacol, Beijing 100029, Peoples R China [2]Beijing Univ Chinese Med, Sch Preclin Med, Beijing 100029, Peoples R China [3]Jinan Univ, Coll Pharm, Inst Tradit Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China [4]Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

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关键词： Catharanthus roseus vinblastine-type N-oxide alkaloids cytotoxicity

摘要：

Two new vinblastine-type N-oxide alkaloids, 17-desacetoxyvinblastine N-b'-oxide (1) and 20-deoxyvinblastine N-b'-oxide (2), were isolated from the leaves of Catharanthus roseus. The structures of 1 and 2 were established by the analysis of their nuclear magnetic resonance and HR-ESI-MS spectroscopic data. All alkaloids were evaluated for their cytotoxic activities against the human hepatocellular carcinoma (HepG2) cell line, human colorectal carcinoma (Lovo) cell line and human breast carcinoma (MCF-7) cell line by the MTT method in vitro, respectively. The results showed that cytotoxic activities of alkaloids 1 and 2 exhibited moderate inhibitory activity on the proliferation of three cancer cells.

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出版当年[2012]版：

大类 | 4 区化学

小类 | 4 区应用化学 4 区药物化学

最新[2025]版：

大类 | 3 区化学

小类 | 3 区应用化学 4 区药物化学

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出版当年[2011]版：

Q3 CHEMISTRY, APPLIED Q4 CHEMISTRY, MEDICINAL

最新[2023]版：

Q3 CHEMISTRY, APPLIED Q3 CHEMISTRY, MEDICINAL

影响因子： 最新[2023版] 1.9 最新五年平均[2021-2025] 2.1 出版当年[2011版] 1.009 出版当年五年平均[2007-2011] 1.053 出版前一年[2010版] 0.906 出版后一年[2012版] 1.031

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第一作者单位： [1]China Japan Friendship Hosp, Inst Clin Med Sci, Dept Pharmacol, Beijing 100029, Peoples R China

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