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Inhibitory Effect of Astragalus Polysaccharides on Lipopolysaccharide-Induced TNF-alpha and IL-1 beta Production in THP-1 Cells

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收录情况： ◇ SCIE

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单位： [1]China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China [2]China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China [3]Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China [4]Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China

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关键词： Astragalus polysaccharides anti-inflammatory macrophage MAPK NF-kappa B

摘要：

Astragalus polysaccharides (APS), one of main bioactive components in Astragalus membranaceus Bunge, has been reported to possess anti- inflammatory activities, but the molecular mechanisms behind this activity are largely unknown. This study aimed to investigate expression of inflammatory cytokines and the MAPK/NF-kappa B pathway in human THP-1 macrophages induced by lipopolysaccharide (LPS). The results showed that the concentrations of TNF-alpha and IL-1 beta released from LPS stimulated THP-1 cells increased significantly compared to control (p < 0.01). After treatment with APS, the TNF-alpha and IL-1 beta levels were significantly lower than those in the LPS group (p < 0.05). The mRNA expression of TNF-alpha and IL-1 beta were also inhibited. Mechanistic studies indicated that APS strongly suppressed NF-kappa B activation and down-regulated the phosphorylation of ERK and JNK, which are important signaling pathways involved in the production of TNF-alpha and IL-1 beta, demonstrating that APS could suppress the production of TNF-alpha and IL-1 beta by LPS stimulated macrophages by inhibiting NF-kappa B activation and ERK and JNK phosphorylation.

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出版当年[2011]版：

大类 | 4 区化学

小类 | 4 区有机化学

最新[2025]版：

大类 | 3 区化学

小类 | 3 区生化与分子生物学 3 区化学：综合

JCR分区：

出版当年[2010]版：

Q2 CHEMISTRY, ORGANIC

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CHEMISTRY, MULTIDISCIPLINARY

影响因子： 最新[2023版] 4.2 最新五年平均[2021-2025] 4.6 出版当年[2010版] 1.988 出版当年五年平均[2006-2010] 1.974 出版前一年[2009版] 1.738 出版后一年[2011版] 2.386

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第一作者单位： [1]China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China

通讯作者：

通讯机构： [1]China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China [4]Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China

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