单位：[1]Tokyo Med Univ, Dept Obstet & Gynecol, Shinjuku Ku, Tokyo 1600023, Japan[2]China Japan Friendship Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
We found that the ubiquitin-conjugating enzyme E2-EPF mRNA is highly expressed in cervical squamous cancer relative to normal tissues and its expression levels positively correlate with clinical stage. Reduction of E2-EPF protein levels by >80% using shRNA decreases the expression levels of HIF-1 alpha, and the proliferation, invasion and tumorigenicity of SiHa, a cervical squamous cancer cell line. E2-EPF knockdown also increases the chemosensitivity to topoisomerase I inhibitor (topotecan) and II (etoposide and doxorubicin). Our results suggest that E2-EPF is associated with the growth and aggressivity of cervical tumor cells. Targeting the E2-EPF pathway may have potential clinical applications for the treatment of cervical cancer.
第一作者单位：[2]China Japan Friendship Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Tokyo Med Univ, Dept Obstet & Gynecol, Shinjuku Ku, Tokyo 1600023, Japan[*1]Tokyo Med Univ, Dept Obstet & Gynecol, Shinjuku Ku, 6-7-1 Nishishinjuku, Tokyo 1600023, Japan
推荐引用方式(GB/T 7714)：
Liang Jing,Nishi Hirotaka,Bian Mei-Lu,et al.The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth[J].ONCOLOGY REPORTS.2012,28(4):1519-1525.doi:10.3892/or.2012.1949.
APA：
Liang, Jing,Nishi, Hirotaka,Bian, Mei-Lu,Higuma, Chinatsu,Sasaki, Toru...&Isaka, Keiichi.(2012).The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth.ONCOLOGY REPORTS,28,(4)
MLA：
Liang, Jing,et al."The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth".ONCOLOGY REPORTS 28..4(2012):1519-1525
