单位：[1]Emory Univ, Dept Anesthesiol, Atlanta, GA 30322 USA[2]Capital Med Univ, Beijing Friendship Hosp, Dept Neurol, Beijing, Peoples R China临床科室神经内科神经内科首都医科大学附属北京友谊医院[3]Emory Univ, Dept Neurol, Atlanta, GA USA
出处：
摘要：
The present study used gene knockout mice to specifically test how deletion of p55 (TNFR1) in the TNF-alpha pathway might affect brain damage following ICH. Fourty-eight hours after ICH induction in mice, we observed an increase in TUNEL positive cells in the basal ganglia and an increase in pro-and active MMP-9 in p55(-/-) animals compared to WT. These data suggest an important protective role of p55 signaling of the TNF-alpha pathway against ICH induced brain damage. Ongoing study on the interplay of p55 with other signaling molecules and inflammatory factors will help us understand the molecular mechanisms of ICH pathology and identify potential targets for treatment of ICH.
语种：
外文
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第一作者：
第一作者单位：[1]Emory Univ, Dept Anesthesiol, Atlanta, GA 30322 USA
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推荐引用方式(GB/T 7714)：
Deveau T. C.,Sun J.,Chen D.,et al.Protective Effect of TNF-alpha p55 gene after Hemorrhage Stroke in Mice[J].NEUROTRAUMA and VASCULAR NEUROSURGERY: JOINT EANS ANNUAL MEETING - 4TH WORLD ICH CONFERENCE 2011.2011,101-105.
APA：
Deveau, T. C.,Sun, J.,Chen, D.,Barnes, A., V,Li, J....&Wei, L..(2011).Protective Effect of TNF-alpha p55 gene after Hemorrhage Stroke in Mice.NEUROTRAUMA and VASCULAR NEUROSURGERY: JOINT EANS ANNUAL MEETING - 4TH WORLD ICH CONFERENCE 2011,,
MLA：
Deveau, T. C.,et al."Protective Effect of TNF-alpha p55 gene after Hemorrhage Stroke in Mice".NEUROTRAUMA and VASCULAR NEUROSURGERY: JOINT EANS ANNUAL MEETING - 4TH WORLD ICH CONFERENCE 2011 .(2011):101-105
