Common variable immunodeficiency disease (CVID) represents a heterogeneous group of primary hypogammaglobulinemias of unknown etiology, characterized by decreased serum immunoglobulin levels and recurrent bacterial infections and is often accompanied by autoimmune disease. Renal involvement is rare in CVID, despite widespread involvement of other organ systems. We describe a 21-year-old girl who presented with recurrent infections, hepatosplenomegaly, renomegaly, and renal insufficiency. Renal biopsy revealed a remarkable diffused interstitial infiltration and severe degenerative tubular lesions. Interstitial infiltration consisted mainly of CD8(+) T cells and CD68(+) macrophages with less CD4(+) T and rare B cells. For the cases with recurrent infections, multiple organomegaly, and renal insufficiency, clinicians should consider to exclude CVID, so as to make the timely diagnosis and appropriate management.
第一作者单位：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Nephrol, Div Nephrol, Beijing 100050, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Nephrol, Div Nephrol, Beijing 100050, Peoples R China[*1]Capital Med Univ, Beijing Friendship Hosp, Dept Nephrol, Div Nephrol, 95 Yong An Rd, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Sha,Zhang Qi-Dong,Zhang Dong-Liang,et al.An Unusual Cause of Renomegaly and Renal Insufficiency: A Case Report of Renal Involvement in Common Variable Immunodeficiency disease[J].RENAL FAILURE.2011,33(1):92-95.doi:10.3109/0886022X.2010.528115.
APA：
Liu, Sha,Zhang, Qi-Dong,Zhang, Dong-Liang&Liu, Wen-Hu.(2011).An Unusual Cause of Renomegaly and Renal Insufficiency: A Case Report of Renal Involvement in Common Variable Immunodeficiency disease.RENAL FAILURE,33,(1)
MLA：
Liu, Sha,et al."An Unusual Cause of Renomegaly and Renal Insufficiency: A Case Report of Renal Involvement in Common Variable Immunodeficiency disease".RENAL FAILURE 33..1(2011):92-95
