单位：[1]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated 6th People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China[2]Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China[3]Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[4]Department of Endocrinology and Metabolism, China-Japan Friendship Hospital, Beijing, China[5]Department of Endocrinology and Metabolism, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China[6]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated 1st People’s Hospital, Shanghai, China[7]Department of Endocrinology and Metabolism, 1st Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China[8]Department of Endocrinology and Metabolism, Fudan University Affiliated Zhongshan Hospital, Shanghai, China[9]Department of Endocrinology and Metabolism, 1st People’s Hospital of Foshan, Foshan, China[10]Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Background: Glycemic variability is increasingly recognized as an important issue in diabetes management. However, the lack of normative values may limit its applicability in the clinical setting. The objective of this study was to establish preliminary normal reference ranges for glycemic variability by analyzing continuous glucose monitoring (CGM) data obtained from healthy Chinese adults. Material/Methods: Three-day CGM data were obtained from 434 healthy adults at 10 academic hospitals throughout China. Glycemic variability was calculated as the 24-hour mean amplitude of glycemic excursions (MACE) and standard deviations (SD) of blood glucose readings. Results: 434 healthy subjects (male 213, female 221; age 43 +/- 14, 20-69 years old; BMI 21.8 +/- 1.7 kg/m(2), 18.5-24.9 kg/m(2)) completed the study. MACE and SD values for the 434 healthy subjects were 1.73 (1.08) mmol/L and 0.75 (0.42) mmol/L [median (interquartile range)], respectively. In both men and women, MACE and SD tended to increase with age. Neither MACE nor SD showed a significant difference between men and women. Values for both parameters were non-normally distributed within the population. The 95(th) percentiles of MACE and SD were 3.86 and 1.40 mmol/L, respectively. These values were adopted as the upper limits of normal. Conclusions: MACE <3.9 mmol/L and SD <1.4 mmol/L are recommended as the normal reference ranges for glycemic variability in Chinese adults. The values established in this study may facilitate the adoption of glycemic variability as a metric of overall glycemic control in diabetes.
第一作者单位：[1]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated 6th People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
通讯作者：
通讯机构：[1]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated 6th People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China[*1]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated 6th People’s Hospital, 600 Yishan Road, Shanghai 200233, China
推荐引用方式(GB/T 7714)：
Zhou Jian,Li Hong,Ran Xingwu,et al.Establishment of normal reference ranges for glycemic variability in Chinese subjects using continuous glucose monitoring[J].MEDICAL SCIENCE MONITOR.2011,17(1):CR9-CR13.doi:10.12659/MSM.881318.
APA：
Zhou, Jian,Li, Hong,Ran, Xingwu,Yang, Wenying,Li, Qiang...&Jia, Weiping.(2011).Establishment of normal reference ranges for glycemic variability in Chinese subjects using continuous glucose monitoring.MEDICAL SCIENCE MONITOR,17,(1)
MLA：
Zhou, Jian,et al."Establishment of normal reference ranges for glycemic variability in Chinese subjects using continuous glucose monitoring".MEDICAL SCIENCE MONITOR 17..1(2011):CR9-CR13
