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Interferon-alpha Induces G1 Cell-Cycle Arrest in Renal Cell Carcinoma Cells Via Activation of Jak-Stat Signaling

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收录情况： ◇ SCIE

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单位： [1]Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing 100050, Peoples R China [2]Capital Med Univ, Dept Pathol, Beijing 100050, Peoples R China

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关键词： IFN-alpha Cell cycle arrest Jaks-Stat Renal cell carcinoma

摘要：

The purpose of this study was to clarify the mechanism of IFN-alpha resistance in RCC. The effects of IFN-alpha on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-alpha was evaluated using Western blotting. The results suggested that IFN-alpha caused growth inhibition of RCC cell lines via arrest in the G1 phase without inducing apoptosis. The resistance of RCC to IFN-alpha was associated with the low expression of Stat1. This study indicated that the Jak-Stat pathway should be considered a primary target for improving the response of RCC to IFN-alpha treatment.

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出版当年[2010]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[2009]版：

Q3 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 最新[2023版] 1.8 最新五年平均[2021-2025] 2.1 出版当年[2009版] 2.105 出版当年五年平均[2005-2009] 2.106 出版前一年[2008版] 1.976 出版后一年[2010版] 2.39

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第一作者单位： [1]Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing 100050, Peoples R China

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