Intima media thickness is a marker for human atherosclerosis. This study aimed to validate the hypothesis that atherosclerosis progression in vivo in mice can be visualized noninvasively using high-resolution ultrasound biomicroscopy (UBM), and to study the association between UBM characteristics and plasma lipids in the apolipoprotein-E knockout (ApoE-/-) mouse model. Four age groups of male ApoE-/- mice were used as atherosclerotic models, with age-matched male C57BL/6 mice used as controls. Plaque thickness and area measured by UBM correlated with histologic measurements (r = 0.81, r = 0.70, respectively; p < 0.001). Serum total cholesterol, low density lipoprotein cholesterol and triglycerides were higher in the ApoE-/- groups compared with controls (p < 0.01). Plaque thickness was correlated with total cholesterol (r = 0.505, p < 0.001). High-resolution UBM provides a noninvasive, accurate means of detecting atherosclerosis progression in vivo in mice and can detect changes in the early stage of atherosclerosis. (E-mail: yangya99@hotmail.com) (C) 2011 World Federation for Ultrasound in Medicine & Biology.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30672000]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [7102044]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2010]版：
大类|3 区医学
小类|2 区声学3 区核医学
最新[2025]版：
大类|3 区医学
小类|3 区声学3 区核医学
JCR分区：
出版当年[2009]版：
Q1ACOUSTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2ACOUSTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者单位：[2]Capital Med Univ, Beijing Friendship Hosp, Dept Ultrasound, Beijing 100029, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing An Zhen Hosp, Dept Ultrasound, Beijing 100029, Peoples R China[*1]Capital Med Univ, Beijing Anzhen Hosp, Dept Ultrasound, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Yanhong,Yang Ya,Xie Jinjie,et al.NONINVASIVE ASSESSMENT OF ATHEROSCLEROSIS IN APOLIPOPROTEIN-E KNOCKOUT MICE BY ULTRASOUND BIOMICROSCOPY[J].ULTRASOUND in MEDICINE and BIOLOGY.2011,37(6):892-899.doi:10.1016/j.ultrasmedbio.2011.02.005.
APA：
Wang, Yanhong,Yang, Ya,Xie, Jinjie,Li, Zhian,Zhang, Xiaoshan&Li, Rongjuan.(2011).NONINVASIVE ASSESSMENT OF ATHEROSCLEROSIS IN APOLIPOPROTEIN-E KNOCKOUT MICE BY ULTRASOUND BIOMICROSCOPY.ULTRASOUND in MEDICINE and BIOLOGY,37,(6)
MLA：
Wang, Yanhong,et al."NONINVASIVE ASSESSMENT OF ATHEROSCLEROSIS IN APOLIPOPROTEIN-E KNOCKOUT MICE BY ULTRASOUND BIOMICROSCOPY".ULTRASOUND in MEDICINE and BIOLOGY 37..6(2011):892-899
