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Suppression of vascular smooth muscle cells' proliferation and migration by valsartan via MAPK pathway

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收录情况： ◇ SCIE

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单位： [1]Capital Med Univ, Beijing Friendship Hosp, Cardiovasc Ctr, Beijing 100050, Peoples R China [2]Yuyao Peoples Hosp, Dept Emergency, Yuyao 315400, Peoples R China

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关键词： Vascular smooth muscle valsartan angiotensin II mitogen-activated protein kinase

摘要：

This study aimed to determine the effects of valsartan on the proliferation and migration of isolated rat vascular smooth muscle cells (VSMCs) and the expression of phospho-p42/44 mitogen-activated protein kinase (MAPK) promoted by angiotensin II (Ang II). VSMCs from the rat thoracic aorta were cultured by attachment-block culture. VSMCs' proliferation and migration were measured by MTT assay and migration chamber system, respectively. Phospho-p42/44 MAPK expression was determined by western blot. Our results reveal that valsartan inhibits Ang II-induced VSMCs' proliferation and migration via suppression of Ang II-induced phospho-P42/44 MAPK expression.

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出版当年[2010]版：

大类 | 4 区工程技术

小类 | 4 区生物工程与应用微生物

最新[2025]版：

无

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出版当年[2009]版：

Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

最新[2023]版：

无

影响因子： 最新[2023版] 0 最新五年平均[2021-2025] 0 出版当年[2009版] 0.565 出版当年五年平均[2005-2009] 0 出版前一年[2008版] 0.547 出版后一年[2010版] 0.573

第一作者：

第一作者单位： [1]Capital Med Univ, Beijing Friendship Hosp, Cardiovasc Ctr, Beijing 100050, Peoples R China

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