Oligodendrocyte transcription factor 1 overexpression promotes oligodendrocyte transcription factor 2 expression in the brains of neonatal rats exposed to hypoxia
To examine the expression profiles of oligodendrocyte transcription factors 1 and 2 (Olig1 and Olig2) and the interaction between these two proteins, Olig1 was transfected into the lateral ventricles of neonatal rats subjected to hypoxia. Immunohistochemistry demonstrated that Olig2 was expressed throughout the nuclei in the brain, and expression increased at 3 days following hypoxia and was higher than levels at 7 days following Ad5-Olig1 transfection. Western blot revealed that Olig1 and Olig2 expression increased in Olig1-transfected brain cells 3 days after hypoxia, but Olig1 and Olig2 expression decreased at 7 days. These results indicate that Olig1 overexpression enhances Olig2 expression in brain tissues of hypoxia rats.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30872778/C1704]; Natural Science Foundation of BeijingBeijing Natural Science Foundation [7072023]; Clinical Basic Cooperation Foundation of Capital Medical University [2009jl18, 11JL-L03]
第一作者单位：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Pediat, Beijing 100050, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Lijun,Cui Hong,Yang Aijun,et al.Oligodendrocyte transcription factor 1 overexpression promotes oligodendrocyte transcription factor 2 expression in the brains of neonatal rats exposed to hypoxia[J].NEURAL REGENERATION RESEARCH.2011,6(34):2713-2717.doi:10.3969/j.issn.1673-5374.2011.34.011.
APA：
Yang, Lijun,Cui, Hong,Yang, Aijun&Jiang, Wenxing.(2011).Oligodendrocyte transcription factor 1 overexpression promotes oligodendrocyte transcription factor 2 expression in the brains of neonatal rats exposed to hypoxia.NEURAL REGENERATION RESEARCH,6,(34)
MLA：
Yang, Lijun,et al."Oligodendrocyte transcription factor 1 overexpression promotes oligodendrocyte transcription factor 2 expression in the brains of neonatal rats exposed to hypoxia".NEURAL REGENERATION RESEARCH 6..34(2011):2713-2717
