Cyclooxygenase-2 (COX-2) has been shown to be upregulated in a variety of tumors so that COX-2 may be a potential target in the treatment of cancer. In order to further explore the mechanism, we used RNA interference to study effects of the inhibition of COX-2 on esophageal squamous cell carcinoma (ESCC) lines. Western blot analysis demonstrated that COX-2 expression was significantly reduced in ESCC cells treated with the COX-2-specific siRNA. Furthermore, the COX-2 siRNA treatment inhibited cell proliferation and induced apoptosis in ESCC cells. In addition, the combination treatment of COX-2 siRNA and acidum acetil salicylicum (aspirin) has a synergistic effect. Therefore, this combination has potential as an anticancer therapy for the treatment of ESCC.
基金：
National 863 High Technology Research and Development Plan of ChinaNational High Technology Research and Development Program of China [2007AA02Z4Z4]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [7072022]
第一作者单位：[1]Capital Univ Med Sci, Beijing Friendship Hosp, Dept Digest Dis, Beijing 100050, Peoples R China[4]Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Li,Tu Jun,Yu Zhong-lin,et al.Effects of the Inhibition of Cyclooxygenase-2 on Human Esophageal Cancer Cells: Inhibition of Cell Proliferation and Induction of Apoptosis[J].PATHOLOGY & ONCOLOGY RESEARCH.2010,16(1):39-45.doi:10.1007/s12253-009-9185-6.
APA：
Zhang, Li,Tu, Jun,Yu, Zhong-lin,Wu, Yong-dong,Xu, Cai-min&Zhang, Shu-tian.(2010).Effects of the Inhibition of Cyclooxygenase-2 on Human Esophageal Cancer Cells: Inhibition of Cell Proliferation and Induction of Apoptosis.PATHOLOGY & ONCOLOGY RESEARCH,16,(1)
MLA：
Zhang, Li,et al."Effects of the Inhibition of Cyclooxygenase-2 on Human Esophageal Cancer Cells: Inhibition of Cell Proliferation and Induction of Apoptosis".PATHOLOGY & ONCOLOGY RESEARCH 16..1(2010):39-45
