Objective: To investigate the role of stomatin-like protein 2 (SLP-2), a novel cancer-related gene, in pulmonary squamous cell carcinoma (PSCC) and its implications. Methods: Immunohistochemical detection of SLP-2 was performed on 96 cases of PSCC with a tissue microarray. Results: SLP-2 was overexpressed in lung cancer compared with normal lung tissue (p < 0.001). High-level SLP-2 expression was significantly correlated with distant metastasis (p = 0.025), decreased overall survival (p = 0.018) and disease-free survival (p = 0.017). SLP-2 overexpression was an independent prognostic factor in multivariate analysis using the Cox regression model (p < 0.05). Conclusion: SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in PSCC. SLP-2 could be regarded as a new significant prognostic biomarker for patients with PSCC.
第一作者单位：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Thorac Surg, Beijing 100050, Peoples R China[*1]Capital Med Univ, Beijing Friendship Hosp, Dept Thorac Surg, 95 Yong An Rd, Beijing 100050, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Thorac Surg, Beijing 100050, Peoples R China[*1]Capital Med Univ, Beijing Friendship Hosp, Dept Thorac Surg, 95 Yong An Rd, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Chang Dong,Ma Kai,Gong Min,et al.SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma[J].BIOMARKERS.2010,15(2):104-110.doi:10.3109/13547500903311910.
APA：
Chang, Dong,Ma, Kai,Gong, Min,Cui, Yong,Liu, Zhi-hua...&Wang, Tian-you.(2010).SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma.BIOMARKERS,15,(2)
MLA：
Chang, Dong,et al."SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma".BIOMARKERS 15..2(2010):104-110
