X-ray diffraction enhanced imaging (DEI) is a phase contrast technique that generates excellent contrast of biological soft tissues compared to conventional absorption radiography. We explore the application of DEI in the diagnosis of hepatic fibrosis. The produced refraction contrast images of fibrous rat liver samples show clearly abnormal liver architectures. Moreover, by comparing to histological pictures, different stages of fibrosis are discriminated, and the corresponding morphological features are analyzed. Besides, quantitative analyses of texture features are presented. The results reported herein show that DEI can be a potential noninvasive technique to diagnose and stage hepatic fibrosis.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [60532090, 30770593]
第一作者单位：[1]Capital Med Univ, Sch Biomed Engn, Beijing 100069, Peoples R China[2]Peking Univ, Hlth Sci Ctr, Dept Med Phys, Beijing 100191, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Hui,Zhang Lu,Wang Xueyan,et al.Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging[J].APPLIED PHYSICS LETTERS.2009,94(12):doi:10.1063/1.3104860.
APA：
Li, Hui,Zhang, Lu,Wang, Xueyan,Wang, Tailing,Wang, Baoen...&Luo, Shuqian.(2009).Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging.APPLIED PHYSICS LETTERS,94,(12)
MLA：
Li, Hui,et al."Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging".APPLIED PHYSICS LETTERS 94..12(2009)
物理