单位：[1]Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China[2]China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China[3]Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China
Magnetite (Fe3O4) nanoparticles were prepared by coprecipitation of Fe3+ and Fe2+ with an aqueous NaOH solution. The Fe3O4-chitosan magnetic composite nanoparticles with a core-shell structure with a diameter of 30-50 nm were synthesized by two steps via a suspension cross-linking method. The inductive heating property of Fe3O4-chitosan composite nanoparticles in an alternating current (AC) magnetic field was investigated. The potential of Fe3O4-chitosan composite nanoparticles was evaluated for localized hyperthermia treatment of cancers. The saturation magnetization, M-s, and coercivity, H-c, were 65.53 emu g(-1) and 0 Oe for Fe3O4 nanoparticles and 24.67 emu g(-1) and 21.69 Oe for Fe3O4-chitosan composite nanoparticles, respectively. After exposed in the AC magnetic field for 29 min, the temperatures of physiological saline suspensions containing Fe3O4 nanoparticles or Fe3O4-chitosan composite nanoparticles were 97.5 degrees C and 53.7 degrees C, respectively. The Fe3O4-chitosan composite nanoparticles would be good thermoseeds for localized hyperthermia cancer therapy. (c) 2008 Elsevier B.V. All rights reserved.
基金：
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [50672004]; National High-Tech Research and Development ProgramNational High Technology Research and Development Program of China [2008AA03Z513]
第一作者单位：[1]Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhao Dong-Lin,Wang Xiu-Xia,Zeng Xian-Wei,et al.Preparation and inductive heating property of Fe3O4-chitosan composite nanoparticles in an AC magnetic field for localized hyperthermia[J].JOURNAL of ALLOYS and COMPOUNDS.2009,477(1-2):739-743.doi:10.1016/j.jallcom.2008.10.104.
APA：
Zhao, Dong-Lin,Wang, Xiu-Xia,Zeng, Xian-Wei,Xia, Qi-Sheng&Tang, Jin-Tian.(2009).Preparation and inductive heating property of Fe3O4-chitosan composite nanoparticles in an AC magnetic field for localized hyperthermia.JOURNAL of ALLOYS and COMPOUNDS,477,(1-2)
MLA：
Zhao, Dong-Lin,et al."Preparation and inductive heating property of Fe3O4-chitosan composite nanoparticles in an AC magnetic field for localized hyperthermia".JOURNAL of ALLOYS and COMPOUNDS 477..1-2(2009):739-743
