单位：[1]Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China临床科室国家中心肝病分中心首都医科大学附属北京友谊医院[2]Shandong Prov Hosp, Dept Gastroenterol, Jinan, Peoples R China
P>De novo hepatitis B virus (HBV) infection after orthotopic liver transplantation (OLT) always progresses to chronic hepatitis because of the patients' immunocompromised status, and only a few then acquire hepatitis B surface antigen (HBsAg) seroconversion even with efficient antiviral therapy. Here we reported the case of a liver transplant recipient with de novo HBV infection who had a favorable outcome after lamivudine (LAM) and adefovir dipivoxil (ADV) antiviral therapy. The patient received OLT because of end-stage primary biliary cirrhosis and was found to have de novo HBV infection 3 months later. She was treated with LAM, and her serum HBV DNA turned undetectable 2 weeks later. However, serum HBV DNA turned detectable again after 9 months of LAM therapy and a YMDD mutation was detected. The addition of ADV was efficient to treat LAM-resistant HBV. After 3 months of combination therapy, LAM was stopped and ADV monotherapy was continued. HBsAg seroconversion was achieved after an additional 12 months. The prevention and treatment of de novo HBV infection after OLT is discussed.
基金：
Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [2006 B54]
第一作者单位：[1]Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang F. K.,Zhang Y.,Zhang J. Y.,et al.Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy[J].TRANSPLANT INFECTIOUS DISEASE.2009,11(6):549-552.doi:10.1111/j.1399-3062.2009.00440.x.
APA：
Zhang, F. K.,Zhang, Y.,Zhang, J. Y.,Jia, J. D.&Wang, B. E..(2009).Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.TRANSPLANT INFECTIOUS DISEASE,11,(6)
MLA：
Zhang, F. K.,et al."Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy".TRANSPLANT INFECTIOUS DISEASE 11..6(2009):549-552
