单位:[1]Vanderbilt Univ, Sch Nursing, Sch Med, Dept Med,Div Dermatol, Nashville, TN 37240 USA[2]Gold Skin Care Ctr, Tennessee Clin Res Ctr, Nashville, TN 37215 USA[3]Capital Univ Med Sci, Beijing Friendship Hosp, Dept Dermatol, Beijing, Peoples R China临床科室皮肤性病科皮肤性病科首都医科大学附属北京友谊医院
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摘要:
Background: Skin aging consists of photoaging and intrinsic aging. It is characterized clinically not only by rhytides, but also by pigmentary alterations and facial telangiectasias. There continues to be a growing interest in the efficacy of intense pulsed light (IPL) devices in the treatment of skin aging, as well as further defining its mechanism of action. Objectives: The objective of this clinical trial was to evaluate the effects and the mechanism of action of an IPL by comparing clinical photographs and biopsy results before and after treatment. Methods. A total of 58 patients were treated using a new IPL device. Clinical photographs were taken before treatment and compared to those taken 3 weeks after the treatment. Also, 4 cases had pathological analyses of tissues that were stained by haematoxylin-eosin and Uana orcein. Immunohistology of human collagen of types I and 3 and quantitative analyses of elastin and collagen were performed by a poly-functional digital image tight microscope; a transmission electron microscope was used for 2 of the cases to look for additional changes. Results: After 3 treatments, 62.1 % of the patients showed improvement in wrinkles and skin texture. Pigmentation improved in 84.6% of the patients, and a reduction in telangiectasis was seen in 81.25% of the patients. Pathological examination showed that both type I and type 3 collagens increased following treatment, but elastin content decreased; however, the elastin fibers were arranged more neatly. In the transmission electron microscope study, the amount of fibroblast activity increased, the fibroblasts were more active, and there were more collagen fibers neatly rearranged within the stroma. Conclusion: Clinical and pathological studies demonstrated that the IPL was effective in improving wrinkles and skin texture. The mechanism of action may be through the increasing activity of the fibroblasts, hyperplasia of the fibroblasts, and rearrangement of both collagen and elastin within the stroma.
第一作者单位:[3]Capital Univ Med Sci, Beijing Friendship Hosp, Dept Dermatol, Beijing, Peoples R China
通讯作者:
通讯机构:[1]Vanderbilt Univ, Sch Nursing, Sch Med, Dept Med,Div Dermatol, Nashville, TN 37240 USA[2]Gold Skin Care Ctr, Tennessee Clin Res Ctr, Nashville, TN 37215 USA[*1]Gold Skin Care Ctr, Tennessee Clin Res Ctr, 2000 Richard Jones Rd,Suite 220, Nashville, TN 37215 USA
推荐引用方式(GB/T 7714):
Feng Yujie,Zhao Junying,Gold Michael H..Skin rejuvenation in Asian skin: The analysis of clinical effects and basic mechanisms of intense pulsed light[J].JOURNAL of DRUGS in DERMATOLOGY.2008,7(3):273-279.
APA:
Feng, Yujie,Zhao, Junying&Gold, Michael H..(2008).Skin rejuvenation in Asian skin: The analysis of clinical effects and basic mechanisms of intense pulsed light.JOURNAL of DRUGS in DERMATOLOGY,7,(3)
MLA:
Feng, Yujie,et al."Skin rejuvenation in Asian skin: The analysis of clinical effects and basic mechanisms of intense pulsed light".JOURNAL of DRUGS in DERMATOLOGY 7..3(2008):273-279