单位：[1]Capital Med Univ, Dept Neurol, Beijing Friendship Hosp, Beijing 100050, Peoples R China临床科室神经内科神经内科首都医科大学附属北京友谊医院[2]Chinese Med Acad, Basic Med Res Inst, Beijing, Peoples R China
The association of atherosclerosis (AS) and Human cytomegalovirus (HCMV) infection was studied. AS plays an important role in the brain stroke and HCMV infection is supposed to be involved in the process of atherosclerotic formation. The presence of HCMV DNA and antigens was examined in the internal carotid arteries collected from 35 patients with ischemic in China. Three methods, immunohistochemistry (IHC), hybridization in situ (HIS), and PCR were used to detect the HCMV immediate early (IE) and late (L) antigens as well as viral DNA in vessel walls. Levels of HCMV IE gene/protein were significantly higher in the stroke group than in control group detected by three methods (IHC 34.3% vs. 10.0%; PCR 20.0% vs. 20.0%). We concluded that the presence of HCMV IE antigen and HCMV DNA in the vessel was associated with the pathological process of AS formation.
第一作者单位：[1]Capital Med Univ, Dept Neurol, Beijing Friendship Hosp, Beijing 100050, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Dept Neurol, Beijing Friendship Hosp, Beijing 100050, Peoples R China[*1]Capital Med Univ, Dept Neurol, Beijing Friendship Hosp, 95 Yongan St, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Yi L.,Lin J. Y.,Gao Y.,et al.DETECTION OF HUMAN CYTOMEGALOVIRUS IN THE ATHEROSCLEROTIC CEREBRAL ARTERIES IN HAN POPULATION IN CHINA[J].ACTA VIROLOGICA.2008,52(2):99-106.
APA：
Yi, L.,Lin, J. Y.,Gao, Y.,Feng, Z. J.&Wang, D. X..(2008).DETECTION OF HUMAN CYTOMEGALOVIRUS IN THE ATHEROSCLEROTIC CEREBRAL ARTERIES IN HAN POPULATION IN CHINA.ACTA VIROLOGICA,52,(2)
MLA：
Yi, L.,et al."DETECTION OF HUMAN CYTOMEGALOVIRUS IN THE ATHEROSCLEROTIC CEREBRAL ARTERIES IN HAN POPULATION IN CHINA".ACTA VIROLOGICA 52..2(2008):99-106
