单位：[1]Nanjing Med Univ, Dept Comp, Nanjing, Peoples R China[2]Nanjing Med Univ, Sch Clin 1, Nanjing, Jiangsu, Peoples R China[3]Beijing Friendship Hosp, Dept Pharm Pediat, Beijing, Peoples R China医技科室药学部首都医科大学附属北京友谊医院[4]Jiangsu Univ, Dept Urinary, Nanjing, Jiangsu, Peoples R China[5]Nanjing Med Univ, Sch Drug, Nanjing, Jiangsu, Peoples R China
The paper proposes the new model of the genetic algorithm and BP neural networks to predict the blood concentration of Cyclosporine. The BP model was optimized by genetic algorithm to overcome the slower convergence speed, and the best result was found in the particular condition with the strong search function of genetic algorithm. The prediction precision of average blood concentration of Cyclosporine by using the GASP neural network model was 97.5%. It was found that the GABP model was superior to BP neural network in the prediction of Cyclosporine blood concentration. We conclude the GABP model can be used in the prediction of the Cyclosporine blood concentration and help clinicians provide better care for patients taking CsA.
基金：
Science Foundation of JiangSu Province Commission of Education [07KJB310075]; The innovation item of the university man in JiangSu, the school fund of NanJing medical university [06NMU007]
语种：
外文
被引次数：
WOS：
第一作者：
第一作者单位：[1]Nanjing Med Univ, Dept Comp, Nanjing, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Shan,Chen Haibing,Yun JunXian,et al.Optimization for Cyclosporine Blood Concentration Prediction Based on Genetic Algorithm - BP Neural Network[J].SECOND INTERNATIONAL CONFERENCE on GENETIC and EVOLUTIONARY COMPUTING: WGEC 2008, PROCEEDINGS.2008,161-+.doi:10.1109/WGEC.2008.99.
APA：
Li, Shan,Chen, Haibing,Yun, JunXian,Zhou, LiuZheng,Xia, Jie...&Yin, Yasha.(2008).Optimization for Cyclosporine Blood Concentration Prediction Based on Genetic Algorithm - BP Neural Network.SECOND INTERNATIONAL CONFERENCE on GENETIC and EVOLUTIONARY COMPUTING: WGEC 2008, PROCEEDINGS,,
MLA：
Li, Shan,et al."Optimization for Cyclosporine Blood Concentration Prediction Based on Genetic Algorithm - BP Neural Network".SECOND INTERNATIONAL CONFERENCE on GENETIC and EVOLUTIONARY COMPUTING: WGEC 2008, PROCEEDINGS .(2008):161-+
