单位：[1]Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing 100081, China[2]Laboratory for Medical Genetics, Institute of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China[3]Department of Neurology, Beijing Friendship Hospital, Affiliate of Capital University of Medical Sciences, Beijing 100050, China临床科室神经内科神经内科首都医科大学附属北京友谊医院[4]Peking Union Medical College, Beijing, China[5]Jiangbin Hospital, Nanning, Guangxi, 530021, China[6]World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China
The oxidative stress caused by nitric oxide (NO) in the brain has been proposed as a pathogenic mechanism in Alzheimer's disease. Endothelial NO synthase (ecNOS) produces the majority of circulating NO. The biological functional and genetic association studies suggested that the Glu298Asp polymorphism of the ecNOS gene (NOS3) may be a genetic risk factor for late-onset Alzheimer's disease (LOAD). To investigate an association between the NOS31 Glu298Asp polymorphism and sporadic LOAD in Chinese, we examined 338 LOAD patients and 378 healthy controls. The associations of the Glu/Glu genotype and Glu allele with LOAD (chi2 = 9.12, df = 1, P = 0.003 by genotype; chi2 = 8.37, df = 1, P = 0.038 by allele) were found. After stratifying by apolipoprotein E allele 4 (APOE epsilon 4) status, increased LOAD risks associated with the Glu/Glu genotype and Glu allele only in the APOE epsilon 4 noncarriers (chi2 = 6.28, df = 1, P = 0.012 by genotype; chi2 = 5.62, df = 1, P = 0.018 by allele) were seen. These results suggest that the NOS3 gene Glu298Asp polymorphism might be a risk factor for LOAD and dependent on APOE epsilon 4 status in Chinese.
基金：
National Basic
Research Program of China (2007CB5119005), the National Infrastructure
Program of Chinese Genetic Resources (2006DKA21300), and the
National Basic Research Program of China (2006CB503900)
第一作者单位：[1]Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing 100081, China[4]Peking Union Medical College, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing 100081, China[4]Peking Union Medical College, Beijing, China[6]World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China
推荐引用方式(GB/T 7714)：
Wang Binbin,Tan Sainan,Yang Ze,et al.Association between Alzheimer's disease and the NOS3 gene Glu298Asp polymorphism in Chinese[J].Journal Of Molecular Neuroscience : MN.2008,34(2):173-6.doi:10.1007/s12031-007-9026-6.
APA：
Wang Binbin,Tan Sainan,Yang Ze,Xie Yan-Chen,Wang Jing...&Ma Xu.(2008).Association between Alzheimer's disease and the NOS3 gene Glu298Asp polymorphism in Chinese.Journal Of Molecular Neuroscience : MN,34,(2)
MLA：
Wang Binbin,et al."Association between Alzheimer's disease and the NOS3 gene Glu298Asp polymorphism in Chinese".Journal Of Molecular Neuroscience : MN 34..2(2008):173-6
