单位：[1]China Japan Friendship Hosp, Dept Pediat, Beijing, Peoples R China[2]China Japan Friendship Hosp, Dept Neurosurg, Beijing 100029, Peoples R China[3]Tsing Hua Univ, China Japan Friendship Hosp, Inst Med Sci, Hsinchu, Taiwan[4]Stanford Univ, Dept Psychol, Stanford, CA 94305 USA[5]Beijing Union Hosp, Dept Pediat, Beijing, Peoples R China[*1]Nihon Univ, Sch Med, Dept Neurosurg, Itabashi Ku, 30-1 Ohyaguchi Kahi Machi, Tokyo 1738610, Japan
Recent neuronal activation studies have demonstrated the presence of regional cerebral blood flow (rCBF) increases in response to neuronal activation in normal newborns. In the present study, using near infrared spectroscopy (NIRS), we evaluated the evoked cerebral blood oxygenation (CBO) changes in hypoxic-ischemic encephalopathy (HIE) of newborns. We studied 20 normal newboms and 22 HIE newborns; mild HIE (n = 9), moderate HIE (n = 7), and severe HIE (it = 6). The babies were from I to 3 days postdelivery. We measured the concentration changes of deoxyhemoglobin (Deoxy-Hb), oxyhemoglobin (Oxy-Hb), and total hemoglobin (Total-Hb) induced by auditory stimulation in the frontal lobes. The normal and HIE groups showed different Oxy-Flb and Total-Hb responses. In normal newborns, 19 out of 20 normal subjects showed increases of Oxy-Hb and Total-Hb, whereas 14 out of 22 subjects showed decreases of Oxy-Hb and Total-Hb during the stimulation (chi(2) = 19.95, p < 0.001), In addition, there was a strong negative correlation between HIE severity and changes of Total-Hb (r = - 0.73, p < 0.001). These results suggest that infants with HIE have decreased rCBF in the frontal lobes during auditory stimulation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
通讯机构：[*1]Nihon Univ, Sch Med, Dept Neurosurg, Itabashi Ku, 30-1 Ohyaguchi Kahi Machi, Tokyo 1738610, Japan
推荐引用方式(GB/T 7714)：
Chen SY,Sakatani K,Lichty W,et al.Auditory-evoked cerebral oxygenation changes in hypoxic-ischemic encephalopathy of newborn infants monitored by near infrared spectroscopy[J].EARLY HUMAN DEVELOPMENT.2002,67(1-2):113-121.doi:10.1016/S0378-3782(02)00004-X.
APA：
Chen, SY,Sakatani, K,Lichty, W,Ning, P,Zhao, SM&Zuo, HC.(2002).Auditory-evoked cerebral oxygenation changes in hypoxic-ischemic encephalopathy of newborn infants monitored by near infrared spectroscopy.EARLY HUMAN DEVELOPMENT,67,(1-2)
MLA：
Chen, SY,et al."Auditory-evoked cerebral oxygenation changes in hypoxic-ischemic encephalopathy of newborn infants monitored by near infrared spectroscopy".EARLY HUMAN DEVELOPMENT 67..1-2(2002):113-121
