单位：[1]China Japan Friendship Inst, Dept Pharmacol, Beijing 100029, Peoples R China[*1]China Japan Friendship Hosp, Dept Heart & Kidney, Beijing 100029, Peoples R China
AIM: To investigate whether allitridum has the effect of pharmacological preconditioning and whether protein kinase C (PKC) plays a role in myocardial protection. METHODS: Thirty-four isolated rabbit hearts which subjected to 30 min of regional myocardial ischemia and 2 h reperfusion, were randomly divided into 5 groups: control group, ischemic preconditioning (PC) group, allitridum (A) group, polymyxin B (Poly B) group, allitridum + polymyxin B (A + PolyB) group. Infarct size was determined by triphenyltetrazolium staining. RESULTS: Pharmacological preconditioning in hearts with a 5-min allitridum infusion 10 min before the prolonged regional ischemia resulted in significantly smaller infarcts (7% +/- 6% of risk area) than in control hearts (25% +/- 7%, P <0.05). There is no significant difference in infarct size between (A + Poly B) group and control hearts (23% +/- 5% vs 25% +/- 7%, P > 0.05). CONCLUSION: These data indicate that allitridium can precondition rabbit ischemic myocardium and this protection can be effectively blocked by administration of Poly B, an inhibitor of PKC, implying that PKC has an important role in preconditioning.
通讯机构：[*1]China Japan Friendship Hosp, Dept Heart & Kidney, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang WJ,Shi ZX,Wang BB,et al.Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C[J].ACTA PHARMACOLOGICA SINICA.2001,22(2):132-136.
APA：
Zhang, WJ,Shi, ZX,Wang, BB,Cui, YJ,Guo, JZ&Li, B.(2001).Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C.ACTA PHARMACOLOGICA SINICA,22,(2)
MLA：
Zhang, WJ,et al."Allitridum mimics effect of ischemic preconditioning by activation of protein kinase C".ACTA PHARMACOLOGICA SINICA 22..2(2001):132-136
