Objective To study the manifestations of Behcet's disease (BD) in the digestive tract and its differential diagnosis from common inflammatory bowel diseases. Methods The symptoms and endoscopic, X-ray's or surgical characteristics of 24 cases of Behcet's disease with digestive tract manifestations were analysed. Results The lesions mainly occurred in tileocecum, and frequently led to hemorrhage that required surgery. The recurrent rare was as high as 77.7%. Conclusion Importance should be attached to early diagnosis of BD of the digestive tract to prevent serious complications.